Memory consolidation drives the enhancement of remote cocaine memory via prefrontal circuit

Remote memory usually decreases over time, whereas remote drug-cue associated memory exhibits enhancement, increasing the risk of relapse during abstinence. Memory system consolidation is a prerequisite for remote memory formation, but neurobiological underpinnings of the role of consolidation in th...

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Bibliographic Details
Published in:Molecular psychiatry 2024-03, Vol.29 (3), p.730-741
Main Authors: Liu, Xiaoxing, Lu, Tangsheng, Chen, Xuan, Huang, Shihao, Zheng, Wei, Zhang, Wen, Meng, Shiqiu, Yan, Wei, Shi, Le, Bao, Yanping, Xue, Yanxue, Shi, Jie, Yuan, Kai, Han, Ying, Lu, Lin
Format: Article
Language:English
Subjects:
101/1
42/44
631/378
692/699/476/5
96/63
Amygdala
Behavioral Sciences
Biological Psychology
Ca2+/calmodulin-dependent protein kinase II
Cocaine
Dendritic spines
Drug self-administration
Medicine
Medicine & Public Health
Neurons
Neurosciences
Pharmacotherapy
Psychiatry
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Summary:Remote memory usually decreases over time, whereas remote drug-cue associated memory exhibits enhancement, increasing the risk of relapse during abstinence. Memory system consolidation is a prerequisite for remote memory formation, but neurobiological underpinnings of the role of consolidation in the enhancement of remote drug memory are unclear. Here, we found that remote cocaine-cue associated memory was enhanced in rats that underwent self-administration training, together with a progressive increase in the response of prelimbic cortex (PrL) CaMKII neurons to cues. System consolidation was required for the enhancement of remote cocaine memory through PrL CaMKII neurons during the early period post-training. Furthermore, dendritic spine maturation in the PrL relied on the basolateral amygdala (BLA) input during the early period of consolidation, contributing to remote memory enhancement. These findings indicate that memory consolidation drives the enhancement of remote cocaine memory through a time-dependent increase in activity and maturation of PrL CaMKII neurons receiving a sustained BLA input.
ISSN:1359-4184
1476-5578
1476-5578
DOI:10.1038/s41380-023-02364-w