Mechanism Exploration of Environmental Pollutants on Premature Ovarian Insufficiency: a Systematic Review and Meta-analysis

As a public health problem, premature ovarian insufficiency leads to infertility or sub-fertility. In addition to premature ovarian insufficiency (POI) increases the lifetime risk of bone fragility, cardiovascular disease, and cognitive impairment. To investigate the effects of environmental polluta...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2024, Vol.31 (1), p.99-106
Main Authors: Zhu, Xiaodan, Liu, Meixia, Dong, Ruoxi, Gao, Liqun, Hu, Jiazhen, Zhang, Xinpei, Wu, Xiaomei, Fan, Bozhen, Chen, Chao, Xu, Wenjuan
Format: Article
Language:English
Subjects:
Embryology
Environmental Pollutants - adverse effects
Female
Gynecologic Oncology: Original Article
Humans
Infertility
Medicine
Medicine & Public Health
Menopause, Premature
Metals, Heavy
Obstetrics/Perinatology/Midwifery
Pharmaceutical Preparations
Phosphatidylinositol 3-Kinases
Primary Ovarian Insufficiency - chemically induced
Reproductive Medicine
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Summary:As a public health problem, premature ovarian insufficiency leads to infertility or sub-fertility. In addition to premature ovarian insufficiency (POI) increases the lifetime risk of bone fragility, cardiovascular disease, and cognitive impairment. To investigate the effects of environmental pollutants on the occurrence of POI and explore its mechanism, we conducted a computer search for articles published in electronic databases by December 13, 2022. Three reviewers independently examined all included studies and scored the qualities of included studies using the Newcastle-Ottawa Scale criteria. In this meta-analysis, eight clinical studies as well as ten preclinical findings showed a pooled OR of 2.331 and 95% CI of 1.968–2.760. This confirms that environmental pollutants, including POPs, heavy metals, PAEs, PAHs, cosmetic and pharmaceutical products, and cigarette smoke, are indeed significant risk factors for POI. In addition, it is demonstrated from the results of this study that signaling pathway of calcium and PI3K Akt and Xpnpep2 , Col1 , Col3 , Col4 , Cx43 , Egr3 , Tff1 , and Ptgs2 genes may all be involved in the process. Environmental pollutants, including POPs, heavy metals, PAEs, PAHs, cosmetic and pharmaceutical products, and cigarette smoke, are indeed significant risk factors for POI.
ISSN:1933-7191
1933-7205
1933-7205
DOI:10.1007/s43032-023-01326-5