Magic ferritin: A novel chemotherapeutic encapsulation bullet

The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin–HCl gives rise to a solution containing five doxorubicin–HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-can...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2005-05, Vol.293 (1), p.509-513
Main Authors: Simsek, Ece, Akif Kilic, Mehmet
Format: Article
Language:English
Subjects:
Apoferritin
Chemotherapy
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Doxorubicin
Encapsulation
Exact sciences and technology
Ferritin
Magnetic properties and materials
Physics
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Summary:The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin–HCl gives rise to a solution containing five doxorubicin–HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2005.01.066