Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible

In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. O...

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Bibliographic Details
Published in:Biomaterials 2006-06, Vol.27 (17), p.3163-3167
Main Authors: Warnke, Patrick H., Wiltfang, Jörg, Springer, Ingo, Acil, Yahya, Bolte, Hendrik, Kosmahl, Markus, Russo, Paul A.J., Sherry, Eugene, Lützen, Ulf, Wolfart, Stefan, Terheyden, Hendrik
Format: Article
Language:English
Subjects:
Biopsy
Bioreactor
Bioreactors
BMP
Bone and Bones - metabolism
Bone and Bones - pathology
Bone Morphogenetic Proteins - metabolism
Bone Regeneration
Bone Substitutes
Humans
In vivo tissue engineering
Male
Mandible - anatomy & histology
Mandible - metabolism
Mandible - pathology
Mandible reconstruction
Mandibular Neoplasms - metabolism
Mandibular Neoplasms - therapy
Middle Aged
Radionuclide Imaging
Reconstructive Surgical Procedures - methods
Replacement
Time Factors
Tissue Engineering - methods
Titanium - chemistry
Tomography, X-Ray Computed
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Summary:In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2006.01.050