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Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible
In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. O...
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| Published in: | Biomaterials 2006-06, Vol.27 (17), p.3163-3167 |
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| Main Authors: | , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c378t-82f8eb0ee2833b23fa996333ec163c4cd8f4ea0b28c6c16cc61dd04cb2a1c3013 |
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| container_end_page | 3167 |
| container_issue | 17 |
| container_start_page | 3163 |
| container_title | Biomaterials |
| container_volume | 27 |
| creator | Warnke, Patrick H. Wiltfang, Jörg Springer, Ingo Acil, Yahya Bolte, Hendrik Kosmahl, Markus Russo, Paul A.J. Sherry, Eugene Lützen, Ulf Wolfart, Stefan Terheyden, Hendrik |
| description | In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials. |
| doi_str_mv | 10.1016/j.biomaterials.2006.01.050 |
| format | article |
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The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2006.01.050</identifier><identifier>PMID: 16504287</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Biopsy ; Bioreactor ; Bioreactors ; BMP ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone Morphogenetic Proteins - metabolism ; Bone Regeneration ; Bone Substitutes ; Humans ; In vivo tissue engineering ; Male ; Mandible - anatomy & histology ; Mandible - metabolism ; Mandible - pathology ; Mandible reconstruction ; Mandibular Neoplasms - metabolism ; Mandibular Neoplasms - therapy ; Middle Aged ; Radionuclide Imaging ; Reconstructive Surgical Procedures - methods ; Replacement ; Time Factors ; Tissue Engineering - methods ; Titanium - chemistry ; Tomography, X-Ray Computed</subject><ispartof>Biomaterials, 2006-06, Vol.27 (17), p.3163-3167</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-82f8eb0ee2833b23fa996333ec163c4cd8f4ea0b28c6c16cc61dd04cb2a1c3013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16504287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warnke, Patrick H.</creatorcontrib><creatorcontrib>Wiltfang, Jörg</creatorcontrib><creatorcontrib>Springer, Ingo</creatorcontrib><creatorcontrib>Acil, Yahya</creatorcontrib><creatorcontrib>Bolte, Hendrik</creatorcontrib><creatorcontrib>Kosmahl, Markus</creatorcontrib><creatorcontrib>Russo, Paul A.J.</creatorcontrib><creatorcontrib>Sherry, Eugene</creatorcontrib><creatorcontrib>Lützen, Ulf</creatorcontrib><creatorcontrib>Wolfart, Stefan</creatorcontrib><creatorcontrib>Terheyden, Hendrik</creatorcontrib><title>Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.</description><subject>Biopsy</subject><subject>Bioreactor</subject><subject>Bioreactors</subject><subject>BMP</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Bone Regeneration</subject><subject>Bone Substitutes</subject><subject>Humans</subject><subject>In vivo tissue engineering</subject><subject>Male</subject><subject>Mandible - anatomy & histology</subject><subject>Mandible - metabolism</subject><subject>Mandible - pathology</subject><subject>Mandible reconstruction</subject><subject>Mandibular Neoplasms - metabolism</subject><subject>Mandibular Neoplasms - therapy</subject><subject>Middle Aged</subject><subject>Radionuclide Imaging</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Replacement</subject><subject>Time Factors</subject><subject>Tissue Engineering - methods</subject><subject>Titanium - chemistry</subject><subject>Tomography, X-Ray Computed</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0EgvL4BRSxYJcwthPXYYcKBaQiNrC2HGdSuUriYicV8PW4aiVYspqH78wdH0KuKGQUqLhZZZV1nR7QW92GjAGIDGgGBRyQCZVTmRYlFIdkAjRnaSkoOyGnIawg1pCzY3JCRRETOZ0Q9aL7RIektRvbL5O42KM2g_O3yTw6JK5JogA_3RJ7N4b2K1l7XGuPdWLGMLjOfsd0sCGMmGK_tD3i9rHTfW2rFs_JUROPxIt9PCPv84e32VO6eH18nt0tUsOnckglayRWgMgk5xXjjS5LwTlHQwU3uallk6OGikkjYssYQesaclMxTQ0Hys_I9W7v2ruPEcOgOhsMtq3uMd6tWEkLLug0Cm93QuNdCB4btfa20_5LUVBbvGql_uJVW7wKqIp44_Dl3mWsOqx_R_c8o-B-J8D4141Fr4Kx2BusrUczqNrZ__j8ACpLlKM</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Warnke, Patrick H.</creator><creator>Wiltfang, Jörg</creator><creator>Springer, Ingo</creator><creator>Acil, Yahya</creator><creator>Bolte, Hendrik</creator><creator>Kosmahl, Markus</creator><creator>Russo, Paul A.J.</creator><creator>Sherry, Eugene</creator><creator>Lützen, Ulf</creator><creator>Wolfart, Stefan</creator><creator>Terheyden, Hendrik</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>20060601</creationdate><title>Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible</title><author>Warnke, Patrick H. ; Wiltfang, Jörg ; Springer, Ingo ; Acil, Yahya ; Bolte, Hendrik ; Kosmahl, Markus ; Russo, Paul A.J. ; Sherry, Eugene ; Lützen, Ulf ; Wolfart, Stefan ; Terheyden, Hendrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-82f8eb0ee2833b23fa996333ec163c4cd8f4ea0b28c6c16cc61dd04cb2a1c3013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biopsy</topic><topic>Bioreactor</topic><topic>Bioreactors</topic><topic>BMP</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - pathology</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Bone Regeneration</topic><topic>Bone Substitutes</topic><topic>Humans</topic><topic>In vivo tissue engineering</topic><topic>Male</topic><topic>Mandible - anatomy & histology</topic><topic>Mandible - metabolism</topic><topic>Mandible - pathology</topic><topic>Mandible reconstruction</topic><topic>Mandibular Neoplasms - metabolism</topic><topic>Mandibular Neoplasms - therapy</topic><topic>Middle Aged</topic><topic>Radionuclide Imaging</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Replacement</topic><topic>Time Factors</topic><topic>Tissue Engineering - methods</topic><topic>Titanium - chemistry</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warnke, Patrick H.</creatorcontrib><creatorcontrib>Wiltfang, Jörg</creatorcontrib><creatorcontrib>Springer, Ingo</creatorcontrib><creatorcontrib>Acil, Yahya</creatorcontrib><creatorcontrib>Bolte, Hendrik</creatorcontrib><creatorcontrib>Kosmahl, Markus</creatorcontrib><creatorcontrib>Russo, Paul A.J.</creatorcontrib><creatorcontrib>Sherry, Eugene</creatorcontrib><creatorcontrib>Lützen, Ulf</creatorcontrib><creatorcontrib>Wolfart, Stefan</creatorcontrib><creatorcontrib>Terheyden, Hendrik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warnke, Patrick H.</au><au>Wiltfang, Jörg</au><au>Springer, Ingo</au><au>Acil, Yahya</au><au>Bolte, Hendrik</au><au>Kosmahl, Markus</au><au>Russo, Paul A.J.</au><au>Sherry, Eugene</au><au>Lützen, Ulf</au><au>Wolfart, Stefan</au><au>Terheyden, Hendrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>27</volume><issue>17</issue><spage>3163</spage><epage>3167</epage><pages>3163-3167</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16504287</pmid><doi>10.1016/j.biomaterials.2006.01.050</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2006-06, Vol.27 (17), p.3163-3167 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| subjects | Biopsy Bioreactor Bioreactors BMP Bone and Bones - metabolism Bone and Bones - pathology Bone Morphogenetic Proteins - metabolism Bone Regeneration Bone Substitutes Humans In vivo tissue engineering Male Mandible - anatomy & histology Mandible - metabolism Mandible - pathology Mandible reconstruction Mandibular Neoplasms - metabolism Mandibular Neoplasms - therapy Middle Aged Radionuclide Imaging Reconstructive Surgical Procedures - methods Replacement Time Factors Tissue Engineering - methods Titanium - chemistry Tomography, X-Ray Computed |
| title | Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible |
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