Analysis of magnetic drug carrier particle capture by a magnetizable intravascular stent—2: Parametric study with multi-wire two-dimensional model

A 2-D mathematical model was developed and used to examine the capture of magnetic drug carrier particles (MDCPs) by a magnetizable intravascular stent (MIS). The roles of both non-stent system parameters, i.e., the blood flow rate, magnetic field strength and direction and MDCP properties, and sten...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2005-05, Vol.293 (1), p.616-632
Main Authors: Chen, Haitao, Ebner, Armin D., Kaminski, Michael D., Rosengart, Axel J., Ritter, James A.
Format: Article
Language:English
Subjects:
Blood flow
Circulatory system
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Drug delivery
Exact sciences and technology
High-gradient magnetic separation
Magnetic drug delivery
Magnetic drug targeting
Magnetic fields
Magnetic implant
Magnetic microspheres
Magnetic properties and materials
Physics
Simulation
Small particles and nanoscale materials
Stent
Studies of specific magnetic materials
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Summary:A 2-D mathematical model was developed and used to examine the capture of magnetic drug carrier particles (MDCPs) by a magnetizable intravascular stent (MIS). The roles of both non-stent system parameters, i.e., the blood flow rate, magnetic field strength and direction and MDCP properties, and stent design parameters, i.e., the MIS radius, its wire radius, number of MIS loops, interwire loop spacing and MIS ferromagnetic material were evaluated over a wide range of plausible conditions. The results showed that the MIS could be a very effective magnetic drug targeting tool with many possible applications.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2005.01.080