Gestational diabetes mellitus in patients undergoing assisted reproductive techniques or conceiving spontaneously: an analysis on maternal and foetal outcomes

Purpose With the rise of medically assisted reproductive techniques (ART) the number of pregnancies complicated by gestational diabetes mellitus (GDM) has increased. The aim of this study was to evaluate retrospectively the outcomes of pregnancies complicated by GDM who conceive trough ART (cases) c...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2024, Vol.47 (7), p.1797-1803
Main Authors: Burlina, S., Dalfrà, M. G., Marchetto, A., Lapolla, A.
Format: Article
Language:English
Subjects:
Birth weight
Cesarean section
Cholesterol
Diabetes mellitus
Diagnosis
Endocrinology
Gestational diabetes
Glucose tolerance
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Neonates
Original Article
Pregnancy
Pregnancy complications
Reproduction
Statistical analysis
Triglycerides
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Summary:Purpose With the rise of medically assisted reproductive techniques (ART) the number of pregnancies complicated by gestational diabetes mellitus (GDM) has increased. The aim of this study was to evaluate retrospectively the outcomes of pregnancies complicated by GDM who conceive trough ART (cases) compared to those who conceived spontaneously (controls). Methods In 670 women with GDM, 229 cases and 441 controls, followed by the Diabetology of Padua, between 2010-2022, clinical-metabolic maternal characteristics and maternal-foetal outcomes were evaluated. Results As for the maternal clinical-metabolic characteristics, plasma glucose levels at 60’ and 120’ under oral glucose tolerance test (OGTT) at time of diagnosis were significantly higher in cases (177.4 ± 31.1 vs 170.9 ± 34.1 mg/dl, p  = 0.016; 151.5 ± 32.2 vs 144.0 ± 33.4 mg/dl, p  = 0.005 respectively). Furthermore, at diagnosis, cases show higher levels of total cholesterol (257 ± 53 mg/dl vs 246 ± 52 mg/dl; p  = 0.012) and triglycerides (199.8 ± 83.2 mg/dl vs 184.9 ± 71.3 mg/dl; p  = 0.02) compared to controls. As for maternal outcomes, thyroid disfunction, was recorded in a higher percentage in case (21.4% vs 14.3%; p  = 0.008), as well as, the frequency of cesarean section (50.3% vs 41.2%; p  = 0.038) and twin pregnancies (16.2% vs 2.5%; p  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-023-02282-2