SARS-CoV-2 biology and host interactions

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Re...

Full description

Saved in:
Bibliographic Details
Published in:Nature reviews. Microbiology 2024-04, Vol.22 (4), p.206-225
Main Authors: Steiner, Silvio, Kratzel, Annika, Barut, G. Tuba, Lang, Reto M., Aguiar Moreira, Etori, Thomann, Lisa, Kelly, Jenna N., Thiel, Volker
Format: Article
Language:English
Subjects:
631/326/596/2555
631/326/596/2557
631/326/596/4130
Biology
Biomedical and Life Sciences
Coronaviruses
COVID-19
COVID-19 vaccines
Disease transmission
Genomes
Glycoproteins
Infectious Diseases
Life cycles
Life Sciences
Medical Microbiology
Microbiology
Middle East respiratory syndrome
Pandemics
Parasitology
Proteins
Public health
Respiratory diseases
Review Article
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Virology
Viruses
Zoonoses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus–host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication. In this Review, Thiel and colleagues summarize our emerging knowledge of the SARS-CoV-2 intracellular life cycle and the molecular functions of the viral proteins, as well as their interaction with the host cell.
ISSN:1740-1526
1740-1534
DOI:10.1038/s41579-023-01003-z