Real‐World Outcomes of Inoperable and Metastatic Cutaneous Head and Neck Melanoma Patients

Objective This study aims to describe the overall survival (OS) and to identify associated prognostic factors in patients with inoperable and metastatic cutaneous melanoma of the head and neck (H&N) region, undergoing modern systemic treatments. Methods This is a retrospective single institution...

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Bibliographic Details
Published in:The Laryngoscope 2024-06, Vol.134 (6), p.2762-2770
Main Authors: Rozendorn, Noa, Shutan, Itay, Feinmesser, Gilad, Grynberg, Shirly, Hodadov, Hadas, Alon, Eran, Asher, Nethanel
Format: Article
Language:English
Subjects:
cutaneous melanoma
Head & neck cancer
immunotherapy
Medical prognosis
Melanoma
Metastasis
real‐world study
survival
targeted therapy
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Summary:Objective This study aims to describe the overall survival (OS) and to identify associated prognostic factors in patients with inoperable and metastatic cutaneous melanoma of the head and neck (H&N) region, undergoing modern systemic treatments. Methods This is a retrospective single institutional study. Data on all consecutive H&N melanoma patients treated with systemic oncologic treatments between 2015 and 2022 were collected from electronic medical files. Kaplan–Meier curves were used to describe survival and Cox regression analysis was used to identify patient and tumor factors associated with prognosis. Results A total of 144 patients were included. Median OS was 45 months (95% confidence interval [CI] 28–65 m). On univariable analysis for OS, the primary disease site, specifically the nape and neck (hazard ratio [HR] 3.3, 95% CI 1.4–7.7, p = 0.007), high Eastern Cooperative Oncology Group Performance Status ([ECOG‐PS], HR 2.5, 95% CI = 1.9–3.3, p 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.31290