Effect of nanometric β-calcium glycerophosphate supplementation in conventional toothpaste on enamel demineralization: An in vitro study

The aim of this study was to evaluate the effects of supplementing toothpastes containing 1100 ppm F with micrometric or nanometric [beta]-calcium glycerophosphate (β-CaGPm/β-CaGPn) on artificial enamel demineralization, using a pH cycling model. Bovine enamel blocks (4 mm × 4 mm, n = 120) selected...

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Published in:Journal of the mechanical behavior of biomedical materials 2024-03, Vol.151, p.106354-106354, Article 106354
Main Authors: Emerenciano, Nayara Gonçalves, Delbem, Alberto Carlos Botazzo, Gonçalves, Francyenne Maira Castro, de Camargo, Emerson Rodrigues, de Souza Neto, Francisco Nunes, Gorup, Luiz Fernando, Silva-Sousa, Yara Teresinha Corrêa, Danelon, Marcelle
Format: Article
Language:English
Subjects:
Animals
Calcium
Cattle
Cross-Sectional Studies
Dietary Supplements
Fluorides - analysis
Fluorides - pharmacology
Glycerophosphates
Hardness
Humans
Hydrogen-Ion Concentration
Tooth Demineralization - prevention & control
Toothpastes - pharmacology
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Summary:The aim of this study was to evaluate the effects of supplementing toothpastes containing 1100 ppm F with micrometric or nanometric [beta]-calcium glycerophosphate (β-CaGPm/β-CaGPn) on artificial enamel demineralization, using a pH cycling model. Bovine enamel blocks (4 mm × 4 mm, n = 120) selected using initial surface hardness were randomly allocated to ten toothpaste groups (n = 12): without fluoride or β-CaGPm or β-CaGPn (Negative control), 1100 ppm F (1100 F), and 1100 ppm F plus 0.125%, 0.25%, 0.5%, and 1.0% of β-CaGPm or β-CaGPn. Blocks were treated two times per day with toothpaste slurry and subjected to five pH cycles (demineralizing and remineralizing solutions) at 37 °C. The final surface hardness, percentage of surface hardness loss (%SH), cross-sectional hardness (ΔKHN), and profile analysis and lesion depth subsurface were analysed using polarized light microscopy (PLM). Fluoride (F), calcium (Ca), and phosphorus (P) concentrations were also measured. Data were analysed using ANOVA and Student-Newman-Keuls tests ([alpha] = 0.001). Blocks treated with 1100 F toothpaste containing 0.5%β-CaGPm or 0.25%β-CaGPn showed with reduced %SH values when compared with those treated with 1100 F alone (p 
ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2023.106354