Control of Neuronal Survival and Development Using Conductive Diamond

This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuro...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2024-01, Vol.16 (4), p.4361-4374
Main Authors: Falahatdoost, Samira, Prawer, Yair D. J., Peng, Danli, Chambers, Andre, Zhan, Hualin, Pope, Leon, Stacey, Alastair, Ahnood, Arman, Al Hashem, Hassan N., De León, Sorel E., Garrett, David J., Fox, Kate, Clark, Michael B., Ibbotson, Michael R., Prawer, Steven, Tong, Wei
Format: Article
Language:English
Subjects:
Biological and Medical Applications of Materials and Interfaces
Cell Survival
Diamond - chemistry
Diamond - pharmacology
Electric Conductivity
Neurons - physiology
Tissue Engineering
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Summary:This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular–substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.3c14680