In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles

Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chroma...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2005-05, Vol.293 (1), p.389-393
Main Authors: Alexiou, Christoph, Jurgons, Roland, Schmid, Roswitha, Hilpert, Andrea, Bergemann, Christian, Parak, Fritz, Iro, Heinrich
Format: Article
Language:English
Subjects:
Cancer treatment
Chemotherapy
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Exact sciences and technology
Ferrofluids
HeLa cells
Magnetic drug targeting
Magnetic liquids
Magnetic properties and materials
Mitoxantrone
Nanoparticles
Physics
Small particles and nanoscale materials
Studies of specific magnetic materials
VX2 Tumor
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Summary:Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2005.02.036