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In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles
Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chroma...
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Published in: | Journal of magnetism and magnetic materials 2005-05, Vol.293 (1), p.389-393 |
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container_issue | 1 |
container_start_page | 389 |
container_title | Journal of magnetism and magnetic materials |
container_volume | 293 |
creator | Alexiou, Christoph Jurgons, Roland Schmid, Roswitha Hilpert, Andrea Bergemann, Christian Parak, Fritz Iro, Heinrich |
description | Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy. |
doi_str_mv | 10.1016/j.jmmm.2005.02.036 |
format | article |
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subjects | Cancer treatment Chemotherapy Condensed matter: electronic structure, electrical, magnetic, and optical properties Exact sciences and technology Ferrofluids HeLa cells Magnetic drug targeting Magnetic liquids Magnetic properties and materials Mitoxantrone Nanoparticles Physics Small particles and nanoscale materials Studies of specific magnetic materials VX2 Tumor |
title | In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles |
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