In vivo biostability of polyether polyurethanes with polyethylene oxide surface-modifying end groups; resistance to biologic oxidation and stress cracking

Polyethylene oxide (PEO) on polymer surfaces has been reported to reduce cellular adhesion, a very desirable property for cardiac pacing leads. A Shore 80A polyether polyurethane with up to 6% PEO surface‐modifying end groups (SME) was evaluated for its chronic in vivo biostability. In a short‐term...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research 2005-10, Vol.75A (1), p.175-184
Main Authors: Ebert, Mike, Ward, Bob, Anderson, James, McVenes, Rick, Stokes, Ken
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Biocompatible Materials - chemistry
Biodegradation, Environmental
biostability
Bone Substitutes - chemistry
Cell Adhesion
environmental stress cracking
Ethers - chemistry
Materials Testing
Microscopy, Electron, Scanning
Models, Chemical
Oxidation-Reduction
Oxygen - chemistry
Oxygen - metabolism
Polyethylene Glycols - chemistry
polyethylene oxide
Polymers - chemistry
polyurethane
Polyurethanes - chemistry
Prosthesis Failure
Rabbits
Spectroscopy, Fourier Transform Infrared - methods
Stress, Mechanical
Surface Properties
surface-modifying end group
Tensile Strength
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polyethylene oxide (PEO) on polymer surfaces has been reported to reduce cellular adhesion, a very desirable property for cardiac pacing leads. A Shore 80A polyether polyurethane with up to 6% PEO surface‐modifying end groups (SME) was evaluated for its chronic in vivo biostability. In a short‐term (12 week) screening test, strained samples appeared to develop the same surface oxidation as unmodified polymer, but did not produce visible cracking ≥500×, prompting a longer‐term study. By the time the longer‐term study was initiated, most of the PEO SME had disappeared from the starting material's surface. After 1 year in vivo, surface oxidation, shallow surface cracking, and environmental stress cracking (ESC) developed on highly strained samples to the point of failure, so that there was no significant difference between the SME polymer and its control (the same polymer without SME). No further change was seen for up to 2 years of implantation. Unstrained PEO SME polymer developed shallow surface cracking, but no ESC up to 2 years of implantation. Thus, PEO SME slightly delayed, but did not stop biodegradation, and under unstrained conditions, has no adverse effect on biostability. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005
ISSN:1549-3296
0021-9304
1552-4965
1097-4636
DOI:10.1002/jbm.a.30396