Esophageal body adaptation to Nissen fundoplication: Increased esophagogastric outflow resistance yields delayed and sustained peristaltic contractions without increased amplitude

Background Improvement in lower esophageal sphincter (LES) competency after laparoscopic Nissen fundoplication (LNF) is well established, yet esophageal body physiology data are limited. We aimed to describe the impact of LNF on whole esophagus physiology using standard and novel manometric characte...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2024-04, Vol.36 (4), p.e14740-n/a
Main Authors: Boris, Lubomyr, Eriksson, Sven E., Sarici, Inanc S., Zheng, Ping, Kuzy, Jacob, Scott, Sarah, Jobe, Blair A., Ayazi, Shahin
Format: Article
Language:English
Subjects:
Dysphagia
esophageal physiology
Esophageal sphincter
Esophagus
high resolution manometry
Laparoscopy
Latency
lower esophageal sphincter (LES)
Muscle contraction
Nissen fundoplication
peristalsis
Physiology
Smooth muscle
Sphincter
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Summary:Background Improvement in lower esophageal sphincter (LES) competency after laparoscopic Nissen fundoplication (LNF) is well established, yet esophageal body physiology data are limited. We aimed to describe the impact of LNF on whole esophagus physiology using standard and novel manometric characteristics. Methods A cohort of patients with an intact fundoplication without herniation and no postoperative dysphagia were selected and underwent esophageal manometry at one‐year after surgery. Pre‐ and post‐operative manometry files were reanalyzed using standard and novel manometric characteristics and compared. Key Results A total of 95 patients were included in this study. At 16.1 (8.7) months LNF increased LES overall and abdominal length and resting pressure (p 
ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.14740