Pancreatosteatosis in patients with adrenal incidentaloma: A risk factor for impaired glucose metabolism

•Patients with adrenal adenoma have an increased risk of developing dysglycemia.•Early prediction of the risk of dysglycemia in these patients may change management.•Computed tomography can detect the presence of pancreatosteatosis.•Pancreatosteatosis may predict the risk of dysglycemia in adrenal i...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2024-02, Vol.208, p.111099-111099, Article 111099
Main Authors: Candemir, Burcu, Kisip, Kadir, Akın, Şafak, Tuba Sanal, Hatice, Taşar, Mustafa, Altunkaynak, Bülent, Ersöz Gülçelik, Neşe
Format: Article
Language:English
Subjects:
Adrenal incidentaloma
Computed tomography
Diabetes mellitus
Dysglycemia
Glucose metabolism
Pancreatosteatosis
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Summary:•Patients with adrenal adenoma have an increased risk of developing dysglycemia.•Early prediction of the risk of dysglycemia in these patients may change management.•Computed tomography can detect the presence of pancreatosteatosis.•Pancreatosteatosis may predict the risk of dysglycemia in adrenal incidentaloma. Patients with adrenal incidentaloma (AI) are at increased risk of impaired glucose metabolism, which is known to be associated with pancreatosteatosis (PS). We aimed to investigate the risk of developing dysglycemia for patients with non-functioning AI (NFAI) versus those without, and whether the presence of PS predicts future dysglycemia in patients with NFAI. In 80 patients with NFAI and 127 controls matched for age, sex, and body mass index, changes in fasting plasma glucose (FPG) and hemoglobin A1c(HbA1c) were evaluated at 2 years. PS was evaluated with data obtained from non-contrast abdominal computed tomography (CT) performed at the initial evaluation. Mean FPG levels increased significantly after 2 years in both groups (P 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2024.111099