Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis

• Published in: Pediatric research 2024-05, Vol.95 (6), p.1432-1440
• Main Authors: Cai, Li-Li, Li, Xuan, Cai, Qiu-Han, Guo, Sheng-Xuan, Zhang, Yi, Sun, Wen-Cong, Zhao, Ze-Hui, Hu, Si-Yuan
• Format: Article
• Language: English
• Subjects: Abdominal Pain - drug therapy; Adolescent; Child; Child, Preschool; Childrens health; Clinical outcomes; Clinical trials; Female; Humans; Irritable bowel syndrome; Irritable Bowel Syndrome - drug therapy; Medicine; Medicine & Public Health; Pediatric Surgery; Pediatrics; Placebo Effect; Placebos; Randomized Controlled Trials as Topic; Response rates; Systematic Review; Treatment Outcome
• ISSN: 0031-3998; 1530-0447; 1530-0447
• DOI: 10.1038/s41390-023-02996-2

Background Irritable bowel syndrome is common in children and exhibits a high placebo response. This study was to explore the placebo response rate and its influencing factors in children with irritable bowel syndrome. Methods A systematic search was performed on Pubmed, Embase, MEDLINE, Cochrane Library, CNKI, Wanfang, and CBM from database inception to March 2022. Randomized controlled trials of irritable bowel syndrome in children were included in the study. The primary outcome was the placebo response rate of improvement. Results Thirteen studies were included, with 445 patients in the placebo group. The rate of improvement and abdominal pain disappearance were 28.2% (95% CI, 16.6–39.9%) and 5% (95% CI, 0–18.4%). The placebo response based on the abdominal pain score was 0.675 (95% CI, 0.203–1.147). The mode of administration ( P