Simultaneous Electrochemical Detection of Dopamine and Uric Acid via Au@Cu‐Metal Organic Framework

The incorporation of noble metals with metal‐organic frameworks (MOFs) are conducive to the simultaneous electrochemical detection of analytes owing to multiple accessible reaction sites. Herein, Au@Cu‐metal organic framework (Au@Cu‐MOF) is successfully synthesized and modified as a screen‐printed c...

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Bibliographic Details
Published in:ChemPlusChem (Weinheim, Germany) Germany), 2024-05, Vol.89 (5), p.e202300686-n/a
Main Authors: Zhou, Feng, Lim, H. N., Ibrahim, I., Endot, N. A., Malek, E. A., Gowthaman, N. S. K.
Format: Article
Language:English
Subjects:
Dopamine
Label-free Electrochemical Sensor
Metal-organic Framework
Noble Metals
Uric Acid
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Summary:The incorporation of noble metals with metal‐organic frameworks (MOFs) are conducive to the simultaneous electrochemical detection of analytes owing to multiple accessible reaction sites. Herein, Au@Cu‐metal organic framework (Au@Cu‐MOF) is successfully synthesized and modified as a screen‐printed carbon electrode (SPCE), which serves as an excellent electrocatalyst for the oxidation of dopamine (DA) and uric acid (UA). The sensor shows a linear range from 10 μM to 1000 μM, with sensitivity and detection limit of 0.231 μA μM−1 cm−2 and 3.40 μM for DA, and 0.275 μA μM−1 cm−2 and 10.36 μM for UA. Au@Cu‐MOF could realize the individual and simultaneous electrochemical sensing of DA and UA, with distinguishable oxidation peak potentials. Moreover, it exhibits reproducibility, repeatability, and stability. Ultimately, the sensor provides an avenue for an ultrasensitive label‐free electrochemical detection of DA and UA. The Au@Cu‐MOF modified screen‐printed carbon electrode (SPCE) exhibited outstanding and effective electrocatalytic properties, leading to significantly enhanced electrochemical performance for both dopamine (DA) and uric acid (UA) compared to electrodes based on Cu‐MOFs and Au NPs. Furthermore, the Au@Cu‐MOF enabled the separate and simultaneous electrochemical detection of DA and UA, with distinguishable oxidation peak potentials, thereby enabling precise quantification of their concentrations in urine and serum samples. This capability holds promise for diverse applications including clinical diagnosis, drug development, and environmental monitoring.
ISSN:2192-6506
2192-6506
DOI:10.1002/cplu.202300686