Simultaneous Electrochemical Detection of Dopamine and Uric Acid via Au@Cu‐Metal Organic Framework

• Published in: ChemPlusChem (Weinheim, Germany) Germany), 2024-05, Vol.89 (5), p.e202300686-n/a
• Main Authors: Zhou, Feng, Lim, H. N., Ibrahim, I., Endot, N. A., Malek, E. A., Gowthaman, N. S. K.
• Format: Article
• Language: English
• Subjects: Dopamine; Label-free Electrochemical Sensor; Metal-organic Framework; Noble Metals; Uric Acid
• ISSN: 2192-6506; 2192-6506
• DOI: 10.1002/cplu.202300686

The incorporation of noble metals with metal‐organic frameworks (MOFs) are conducive to the simultaneous electrochemical detection of analytes owing to multiple accessible reaction sites. Herein, Au@Cu‐metal organic framework (Au@Cu‐MOF) is successfully synthesized and modified as a screen‐printed carbon electrode (SPCE), which serves as an excellent electrocatalyst for the oxidation of dopamine (DA) and uric acid (UA). The sensor shows a linear range from 10 μM to 1000 μM, with sensitivity and detection limit of 0.231 μA μM−1 cm−2 and 3.40 μM for DA, and 0.275 μA μM−1 cm−2 and 10.36 μM for UA. Au@Cu‐MOF could realize the individual and simultaneous electrochemical sensing of DA and UA, with distinguishable oxidation peak potentials. Moreover, it exhibits reproducibility, repeatability, and stability. Ultimately, the sensor provides an avenue for an ultrasensitive label‐free electrochemical detection of DA and UA. The Au@Cu‐MOF modified screen‐printed carbon electrode (SPCE) exhibited outstanding and effective electrocatalytic properties, leading to significantly enhanced electrochemical performance for both dopamine (DA) and uric acid (UA) compared to electrodes based on Cu‐MOFs and Au NPs. Furthermore, the Au@Cu‐MOF enabled the separate and simultaneous electrochemical detection of DA and UA, with distinguishable oxidation peak potentials, thereby enabling precise quantification of their concentrations in urine and serum samples. This capability holds promise for diverse applications including clinical diagnosis, drug development, and environmental monitoring.