Cardiac injury in hospitalized patients with severe fever and thrombocytopenia syndrome

• Published in: Journal of medical virology 2024-01, Vol.96 (1), p.e29375-n/a
• Main Authors: Ding, Wenqian, Gong, Chen, Meng, Tao, Xiang, Xinjian, Hong, Baoyu, Shen, Shichun, Ding, Shenggang
• Format: Article
• Language: English
• Subjects: Abnormalities; Biomarkers; Blood levels; cardiac injury; Communicable Diseases, Emerging; Creatine; Creatine kinase; Creatine Kinase, MB Form; EKG; Electrocardiography; Fever; Hazards; Health hazards; Heart Injuries; Heart rate; Hospital costs; Hospitalization; Hospitals; Humans; Infectious diseases; Injuries; Injury analysis; Intensive care units; Kinases; Mortality; Mortality risk; Natriuretic Peptide, Brain; novel Bunyavirus; Peptides; Regression analysis; severe fever and thrombocytopenia syndrome; Severe Fever with Thrombocytopenia Syndrome - epidemiology; Thrombocytopenia; Thrombocytopenia - epidemiology; Troponin; Virology
• ISSN: 0146-6615; 1096-9071; 1096-9071
• DOI: 10.1002/jmv.29375

Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease with a high fatality rate. Cardiac injury in SFTS patients is a major concern. This study aimed to evaluate the prevalence of cardiac injury and its association with mortality in hospitalized patients infected with novel Bunyavirus. Cardiac injury was defined as the presence of any of the following abnormalities: (1) blood levels of cardiac biomarkers (creatine kinase‐MB, troponin‐I, B‐type natriuretic peptide or N‐terminal pro‐B‐type natriuretic peptide); (2) new abnormalities in electrocardiography. The 203 SFTS patients were included in the final analysis. The proportion of SFTS patients developing cardiac injury during hospitalization was 71.4% (145/203). Compared with the uninjured group, the cardiac injury group had the severity of cardiac injury was underscored by higher median hospital costs (31420 vs. 12911, p