Protective effect of misoprostol against paclitaxel-induced cardiac damage in rats

One of the most critical reasons for limiting cancer treatment is the toxic effects of anti-cancer drugs on healthy tissues and organs. This study aims to investigate the possible protective effects of misoprostol (MS) against the damage that arises from paclitaxel (PT), an anti-cancer pharmacologic...

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Bibliographic Details
Published in:Prostaglandins & other lipid mediators 2024-04, Vol.171, p.106813-106813, Article 106813
Main Authors: Aktaş, İbrahim, Gur, Fatih Mehmet, BİLGİÇ, Sedat
Format: Article
Language:English
Subjects:
Animals
Antioxidant
Antioxidants - metabolism
Female
Glutathione - metabolism
Heart damage
Inflammation
Misoprostol
Misoprostol - metabolism
Misoprostol - pharmacology
Myocardium - metabolism
Oxidative Stress
Paclitaxel
Paclitaxel - toxicity
Rat
Rats
Rats, Sprague-Dawley
Rats, Wistar
Saline Solution - metabolism
Saline Solution - pharmacology
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Summary:One of the most critical reasons for limiting cancer treatment is the toxic effects of anti-cancer drugs on healthy tissues and organs. This study aims to investigate the possible protective effects of misoprostol (MS) against the damage that arises from paclitaxel (PT), an anti-cancer pharmacological agent, in the rat heart using histopathological and biochemical analyses. In this study, four groups, each containing seven animals, were formed by random selection from 28 Sprague Dawley female rats. Control group rats were administered 1 ml of normal saline orally and intraperitoneally (i.p.) for six days. While the PT group rats were administered PT at a dose of 2 mg/kg intraperitoneally (i.p.) on days 0, 2, 4, and 6, the MS group was administered MS at a dose of 0.2 mg/kg in 1 ml normal saline by oral gavage for six days. PT and MS were administered to the PT + MS group rats in the same dose and route as the previous groups. Administration of PT increased serum lactate dehydrogenase (LDH), cardiac troponin I (cTn-I), creatine kinase isoenzyme MB (CK-MB), and brain natriuretic peptide (BNP) levels. PT administration also decreased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in the heart tissue while increasing the level of malondialdehyde (MDA) (p 
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2024.106813