Exploring the multifaceted impact of lanthanides on physiological pathways in human breast cancer cells

Lanthanum (La) and cerium (Ce), rare earth elements with physical properties similar to calcium (Ca), are generally considered non-toxic when used appropriately. However, their ions possess anti-tumor capabilities. This investigation explores the potential applications and mechanisms of LaCl3 or CeC...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2024-02, Vol.502, p.153731-153731, Article 153731
Main Authors: Huang, Yi-Ming, Hsu, Tsu-Yu, Liu, Ching-Yu, Hsieh, Yu-Chen, Lai, Kuan-Yun, Yang, Ya-Wen, Lo, Kai-Yin
Format: Article
Language:English
Subjects:
Calcium
Cell Line, Tumor
Cisplatin
Cytoskeleton assembly
Humans
Lanthanides
Lanthanoid Series Elements
Lanthanum - toxicity
Nucleolar stress
Phosphatidylinositol 3-Kinases - metabolism
Protein homeostasis
Triple Negative Breast Neoplasms - metabolism
Triple-negative breast cancer
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Summary:Lanthanum (La) and cerium (Ce), rare earth elements with physical properties similar to calcium (Ca), are generally considered non-toxic when used appropriately. However, their ions possess anti-tumor capabilities. This investigation explores the potential applications and mechanisms of LaCl3 or CeCl3 treatment in triple-negative breast cancer (TNBC) cell lines. TNBC, characterized by the absence of estrogen receptor (ERα), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression, is prone to early metastasis and resistant to hormone therapy. Our results demonstrate that La/Ce treatment reduces cell growth, and when combined with cisplatin, it synergistically inhibits cell growth and the PI3K/AKT pathway. La and Ce induce oxidative stress by disrupting mitochondrial function, leading to protein oxidation. Additionally, they interfere with protein homeostasis and induce nucleolar stress. Furthermore, disturbance in F-actin web formation impairs cell migration. This study delves into the mechanism by which calcium-like elements La and Ce inhibit breast cancer cell growth, shedding light on their interference in mitochondrial function, protein homeostasis, and cytoskeleton assembly. ●La/Ce inhibits the growth of breast cancer cells with cisplatin synergistically.●La/Ce induces oxidative stress through mitochondrial dysfunction.●La/Ce interferes with protein homeostasis and induces nucleolar stress.●La/Ce disturbs F-actin web formation and impairs cell migration.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2024.153731