Application of the LADA Strategy for the Synthesis of Unnatural Amino Acids through 1,2-Aryl Migration of Allylic Alcohols

Unnatural amino acids are versatile building blocks. Herein, we report the application of the LADA strategy for the direct synthesis of unnatural amino acids through 1,2-aryl migration of allylic alcohols. This reaction proceeds under mild conditions, tolerates diverse functionalities, and works smo...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-02, Vol.89 (3), p.1543-1551
Main Authors: Miao, Pannan, Zhang, Mengyao, Ni, Zhuojun, Chen, Qi, Sun, Zhankui
Format: Article
Language:English
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Summary:Unnatural amino acids are versatile building blocks. Herein, we report the application of the LADA strategy for the direct synthesis of unnatural amino acids through 1,2-aryl migration of allylic alcohols. This reaction proceeds under mild conditions, tolerates diverse functionalities, and works smoothly on different thiols.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02173