Major stress in early childhood strengthens the association between peripheral inflammatory activity and corticostriatal responsivity to reward

• Published in: Brain, behavior, and immunity behavior, and immunity, 2024-03, Vol.117, p.215-223
• Main Authors: Miller, Gregory E., Carroll, Ann L., Armstrong, Casey C., Craske, Michelle G., Zinbarg, Richard E., Bookheimer, Susan Y., Ka-Yi Chat, Iris, Vinograd, Meghan, Young, Katherine S., Nusslock, Robin
• Format: Article
• Language: English
• Subjects: Children; Cytokines; Inflammation; Reward; Stress; Ventral striatum
• ISSN: 0889-1591; 1090-2139; 1090-2139
• DOI: 10.1016/j.bbi.2024.01.013

•Inflammation was associated with higher corticostriatal responsivity to reward.•This relationship was strongest in participants exposed to major early-life stress.•These patterns were specific to stress in early childhood, from ages 0-8. Severe, chronic stress during childhood accentuates vulnerability to mental and physical health problems across the lifespan. To explain this phenomenon, the neuroimmune network hypothesis proposes that childhood stressors amplify signaling between peripheral inflammatory cells and developing brain circuits that support processing of rewards and threats. Here, we conducted a preliminary test of the basic premises of this hypothesis. 180 adolescents (mean age = 19.1 years; 68.9 % female) with diverse racial and ethnic identities (56.1 % White; 28.3 % Hispanic; 26.1 % Asian) participated. The Childhood Trauma Interview was administered to quantify early adversity. Five inflammatory biomarkers were assayed in antecubital blood — C-reactive protein, tumor necrosis factor-a, and interleukins-6, −8, and −10 — and were averaged to form a composite score. Participants also completed a functional MRI task to measure corticostriatal responsivity to the anticipation and acquisition of monetary rewards. Stress exposure and corticostriatal responsivity interacted statistically to predict the inflammation composite. Among participants who experienced major stressors in the first decade of life, higher inflammatory activity covaried with lower corticostriatal responsivity during acquisition of monetary rewards. This relationship was specific to participants who experienced major stress in early childhood, implying a sensitive period for exposure, and were evident in both the orbitofrontal cortex and the ventral striatum, suggesting the broad involvement of corticostriatal regions. The findings were independent of participants’ age, sex, racial and ethnic identity, family income, and depressive symptoms. Collectively, the results are consistent with hypotheses suggesting that major stress in childhood alters brain-immune signaling.