Tumour deposits are independently associated with recurrence in colon cancer

• Published in: Colorectal disease 2024-03, Vol.26 (3), p.459-465
• Main Authors: Hakki, Lynn, Khan, Asama, Do, Eric, Gonen, Mithat, Firat, Canan, Vakiani, Efsevia, Shia, Jinru, Widmar, Maria, Wei, Iris H., Smith, J. Joshua, Pappou, Emmanouil P., Nash, Garrett M., Paty, Philip B., Garcia‐Aguilar, Julio, Weiser, Martin R.
• Format: Article
• Language: English
• Subjects: Colon cancer; Colorectal cancer; lymph node metastasis; Lymph nodes; Lymphatic system; Malignancy; Medical records; Mesentery; Metastases; Metastasis; Nerves; Pathology; Patients; recurrence risk; Risk factors; tumor deposits; Tumors
• ISSN: 1462-8910; 1463-1318
• DOI: 10.1111/codi.16873

Aim Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients. Method Clinicopathological variables were collected from the medical records of patients with Stage I–III colon cancer who underwent resection in 2017–2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded. Results Tumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p