Effect of calcium and Vitamin D supplementation on residual ridge resorption in edentulous patients: An open-label randomized study

• Published in: The journal of Indian Prosthodontic Society 2024-01, Vol.24 (1), p.52-60
• Main Authors: Singh, Saumyendra Vikram, Aggarwal, Himanshi, Khandpur, Mani, Trivedi, Shilpa, Pathak, Anupama, Arya, Deeksha
• Format: Article
• Language: English
• Subjects: Alfacalcidol; Bone mineral density; Bone resorption; Calcifediol; Calcium; Calcium, Dietary; Compact disc industry; Computed tomography; Dental prosthetics; Dentures; Dietary Supplements; Edentulous; Humans; Mouth, Edentulous; Quality of Life; Resorption; Statistical analysis; Tiludronate; Vitamin D
• ISSN: 0972-4052; 1998-4057; 1998-4057
• DOI: 10.4103/jips.jips_455_23

Complete dentures (CDs) are fabricated to rehabilitate the edentulous. Severe residual ridge resorption (RRR) compromises CD functionality, adversely affecting function, appearance, systemic health, and quality of life. The purpose of this study was to assess the benefit, if any, of calcium and Vitamin D supplementation on the rate of RRR. Retarding RRR would improve treatment prognosis and make CD fabrication less demanding. This longitudinal, parallel, open-label randomized study was conducted in the Department of Prosthodontics of the institute. One hundred and fifty edentulous subjects underwent bone mineral density (BMD) assessment followed by CD fabrication to measure RR height and width with computerized tomographic (CT) scans. Subjects were randomized to oral supplementation group - S, given combined Vitamin D and calcium daily, and nonsupplementation group - NS. Subjects from both the groups were followed up with repeat BMD test and CT scan after 12 months. Mean BMD, RR height and width, and RRR values were collected, analyzed, and compared for the two groups using STATA 17. Baseline mean T-score, RR height, and RR width were - 1.84, 22.30 mm, and 4.25 mm, respectively, for the sample. In both Groups S and NS, a statistically significant decrease in mandibular RR height (P = 0.000 for both) and width (P = 0.027 and 0.003, respectively) was observed at 1-year follow-up. There was a statistically insignificant difference between Groups S and NS for mean BMD, T-score, RR height and width, and RRR at both baseline and 12-month follow-up. One-year RRR rate for Group S (1.30 mm) was insignificantly lesser than for group NS (1.33 mm). Short-term oral calcium and Vitamin D supplementation was ineffective in reducing RRR and improving BMD.