Hospitalization-based epidemiology of systemic and cardiac amyloidosis in the Veneto Region, Italy

• Published in: International journal of cardiology 2024-04, Vol.400, p.131804-131804, Article 131804
• Main Authors: De Michieli, Laura, Stoppa, Giorgia, Sinigiani, Giulio, Previato, Lorenzo, Lorenzoni, Giulia, Salvalaggio, Alessandro, Berno, Tamara, Perazzolo Marra, Martina, Briani, Chiara, Iliceto, Sabino, Biggeri, Annibale, Catelan, Dolores, Cipriani, Alberto
• Format: Article
• Language: English
• Subjects: Cardiac amyloidosis; Epidemiology; Hospitalizations; Incidence; Prevalence; Systemic amyloidosis
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2024.131804

Defining the epidemiology of systemic and cardiac amyloidosis (CA) is a contemporary challenge. The present study aimed to estimate incidence and time trends in amyloidosis-related hospitalizations (AH) in Veneto Region (5 million inhabitants, Northeastern Italy). International Classification of Diseases (ICD-9) codes were used to identify AH in Veneto from 2010 to 2020. AH were defined as any hospitalization with a discharge summary reporting an ICD-9 code for systemic amyloidosis. Hospitalization for CA was defined as records with ICD-9 code for systemic amyloidosis and ICD-9 code for heart failure,cardiomyopathy or arrhythmia. Hospital/outpatient encounters for carpal tunnel syndrome (CTS) surgeries also were extracted. AH incidence was estimated using a buffer of 5 years. In the time range 2015–2020, the incidence rate of AH was 23.5 cases per 106 (95% confidence interval, CI, 21.8; 25.3), mainly affecting patients>65 years (76.2%) and males (63.5%), with a progressively increasing trend (percent annual increase 17%, 95% CI 12; 22%). The 10 year prevalence of AH in 2020 was 124.5 per 106 (95% CI 114.9; 134.8). In 2020, annual hospitalized prevalent cases of CA were about 70% of all cases (159/228), mainly patients >65 years and males. Among patients with multiple CTS surgeries, a subsequent code for cardiac disease was found in 913 after a median of 3.9 years, more frequently in men than in women (463/6.526 7.1% versus 450/11.406 3.9%). In Veneto, we recorded a significantly increasing trend in the incidence of AH, with concordant increasing prevalence estimates. Hospitalization-based incidence and estimated prevalence of systemic amyloidosis in the Veneto region, northeastern Italy. Veneto region is a region of around 5 million inhabitants (specific annual population figures based on data obtained from the Italian National Institute of statistics). International classification of diseases (ICD-9) codes were used to identify amyloidosis-related hospitalization (AH) in Veneto region from 2010 to 2020. On the right of the figure, a progressively increasing incidence of AH is reported. Based on such incidence and survival probability, a 10-year period prevalence in 2020 of 124.5 per 106 was estimated. Abbreviations: CI, confidence interval [Display omitted] •To define the epidemiology of systemic and cardiac amyloidosis is a contemporary challenge.•In Veneto Region (5 million inhabitants, Italy), amyloidosis hospitalization incidence is increasing, partic