Infectious keratitis following corneal transplantation: A long‐term cohort study

Background To assess the long‐term incidence and risk factors for post‐keratoplasty infectious keratitis (IK), associated ocular pathogens, and antibiotic resistance profiles. Methods Cohort study including 2553 consecutive penetrating, endothelial, and anterior lamellar keratoplasties performed bet...

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Bibliographic Details
Published in:Clinical & experimental ophthalmology 2024-05, Vol.52 (4), p.402-415
Main Authors: Ittah‐Cohen, Ian, Knoeri, M. Juliette, Bourcier, Tristan, Merabet, Lilia, Bouheraoua, Nacim, Borderie, Vincent M.
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Carbapenems
Cohort analysis
Cornea
Corneal transplantation
Drug resistance
Fluoroquinolones
Graft rejection
infectious keratitis
Keratitis
keratoplasty
Patients
Penicillin
Rifamycins
Risk factors
Ticarcillin
Transplantation
Vancomycin
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Summary:Background To assess the long‐term incidence and risk factors for post‐keratoplasty infectious keratitis (IK), associated ocular pathogens, and antibiotic resistance profiles. Methods Cohort study including 2553 consecutive penetrating, endothelial, and anterior lamellar keratoplasties performed between 1992 and 2020. Medical and microbiological records of patients clinically diagnosed with IK were retrospectively reviewed. Main outcome measures: cumulative incidence of IK, infectious agent species, and antibiotics resistance profiles. Results The average follow‐up time after transplantation was 112 ± 96 months. Eighty‐nine IK episodes were recorded; microbiological tests were positive in 55/89 (62%). The cumulated incidence of postoperative IK was 5.50%/10.25% at 10/20 years. The occurrence of at least one episode of IK after transplantation was associated with lower graft survival in the long term (p 
ISSN:1442-6404
1442-9071
DOI:10.1111/ceo.14354