Endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling

Advances in next-generation sequencing have made comprehensive genomic profiling (CGP) using tumor tissue specimens and liquid biopsy using blood samples feasible in routine clinical practice. In the context of pancreaticobiliary cancer, it is necessary to consider CGP in formulating individualized...

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Bibliographic Details
Published in:Journal of medical ultrasonics (2001) 2024-04, Vol.51 (2), p.253-260
Main Authors: Okuno, Nozomi, Hara, Kazuo
Format: Article
Language:English
Subjects:
Bile ducts
Breast cancer
Cancer
Cancer therapies
Cholangiocarcinoma
Genes
Genetic testing
Imaging
Medical diagnosis
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
Mutation
Ovarian cancer
Pancreatic cancer
Precision medicine
Radiology
Reimbursement
Response rates
Special Feature: Review Article
Tumors
Ultrasound
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Summary:Advances in next-generation sequencing have made comprehensive genomic profiling (CGP) using tumor tissue specimens and liquid biopsy using blood samples feasible in routine clinical practice. In the context of pancreaticobiliary cancer, it is necessary to consider CGP in formulating individualized treatment strategies. Performing CGP with tumor tissue specimens requires a sufficient number of high-quality samples. EUS-guided tissue acquisition (EUS-TA) is expected to play a significant role in this regard, and endosonographers need to address this role. Here, we review the current status of EUS-TA for CGP focusing on pancreatic cancer and biliary tract cancer.
ISSN:1346-4523
1613-2254
1613-2254
DOI:10.1007/s10396-023-01403-x