A novel bola-molecular self-assembling hydrogel for enhancing diabetic wound healing

Chronic wounds, particularly those caused by diabetes, pose a significant challenge for clinical treatment due to their prolonged healing process and associated complications, which can lead to increased morbidity. A biocompatible hydrogel with strong antibacterial properties and the ability to prom...

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Bibliographic Details
Published in:Journal of colloid and interface science 2024-04, Vol.659, p.385-396
Main Authors: Guo, Linqing, Lan, Jinxi, Li, Jianhua, Song, Yibo, Wang, Xinlong, Zhao, Yongshan, Yuan, Yue
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Copper - pharmacology
Diabetes Mellitus
Humans
Hydrogels - chemistry
Hydrogels - pharmacology
Wound Healing
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Summary:Chronic wounds, particularly those caused by diabetes, pose a significant challenge for clinical treatment due to their prolonged healing process and associated complications, which can lead to increased morbidity. A biocompatible hydrogel with strong antibacterial properties and the ability to promote angiogenesis can be directly absorbed in the wound site for healing. A series of self-healing, antibacterial bolaamphiphilic supramolecular self-assembling hydrogels (HLQMes/Cu) were developed based on metal-ligand coordination between various concentrations of Cu solution and the head group of l-histidine methyl ester in HLQMes. This is the first report on the application of bola-molecular supramolecular hydrogels for the treatment of chronic wounds. The bola-molecular hydrogels reduced the toxicity of copper ions by coordination, and the HLQMes/Cu hydrogel, with 1.3 mg/mL Cu (HLQMes/Cu1.3), demonstrated good biocompatibility and antibacterial properties and effectively enhanced wound healing in a diabetic wound model with full-thickness injuries. Immunohistochemical analysis revealed that the HLQMes/Cu1.3 hydrogel enhanced epithelial formation and collagen deposition in wounds. Immunofluorescence studies confirmed that the HLQMes/Cu1.3 hydrogel attenuated the expression of proinflammatory factor (IL-6) and promoted angiogenesis by upregulating α-SMA and CD31. These findings demonstrate the potential of this bolaamphiphilic supramolecular self-assembling hydrogel as a promising candidate for diabetic wound treatment.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2023.12.100