Spinal cord injury: Olfactory ensheathing cell‐based therapeutic strategies

Spinal cord injury (SCI) is a highly disabling neurological disorder that is difficult to treat due to its complex pathophysiology and nerve regeneration difficulties. Hence, effective SCI treatments are necessary. Olfactory ensheathing cells (OECs), glial cells derived from the olfactory bulb or mu...

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Bibliographic Details
Published in:Journal of neuroscience research 2024-01, Vol.102 (1), p.e25283-n/a
Main Authors: Chen, Xinli, Liu, Yibin, Stavrinou, Pantelis, Stavrinou, Lampis, Hu, Weipeng, Goldbrunner, Roland, Zheng, Feng, He, Hefan
Format: Article
Language:English
Subjects:
Animal models
Biomaterials
Biomedical materials
cell transplantation
central nervous system
Genetic modification
Glial cells
Nerves
Neurological diseases
Neuroprotection
Olfaction
Olfactory bulb
Olfactory ensheathing cells
Regeneration
Regeneration (biological)
regenerative medicine
Spinal cord
Spinal cord injuries
Transplantation
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Description
Summary:Spinal cord injury (SCI) is a highly disabling neurological disorder that is difficult to treat due to its complex pathophysiology and nerve regeneration difficulties. Hence, effective SCI treatments are necessary. Olfactory ensheathing cells (OECs), glial cells derived from the olfactory bulb or mucosa, are ideal candidates for SCI treatment because of their neuroprotective and regenerative properties, ample supply, and convenience. In vitro, animal model, and human trial studies have reported discoveries on OEC transplantation; however, shortcomings have also been demonstrated. Recent studies have optimized various OEC transplantation strategies, including drug integration, biomaterials, and gene editing. This review aims to introduce OECs mechanisms in repairing SCI, summarize the research progress of OEC transplantation‐optimized strategies, and provide novel research ideas for SCI treatment.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.25283