Utilising biosensor‐based approaches for identifying neurotropic viruses

Neurotropic viruses, with their ability to invade the central nervous system, present a significant public health challenge, causing a spectrum of neurological diseases. Clinical manifestations of neurotropic viral infections vary widely, from mild to life‐threatening conditions, such as HSV‐induced...

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Bibliographic Details
Published in:Reviews in medical virology 2024-01, Vol.34 (1), p.e2513-n/a
Main Authors: Alissa, Mohammed, Hjazi, Ahmed
Format: Article
Language:English
Subjects:
Biosensing Techniques
Biosensors
Central nervous system
diagnostic methods
Encephalitis
Humans
Nervous System Diseases
Neurological diseases
neurotropic viruses
Poliomyelitis
Public health
Surface plasmon resonance
virus detection
Viruses
Viruses - genetics
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Summary:Neurotropic viruses, with their ability to invade the central nervous system, present a significant public health challenge, causing a spectrum of neurological diseases. Clinical manifestations of neurotropic viral infections vary widely, from mild to life‐threatening conditions, such as HSV‐induced encephalitis or poliovirus‐induced poliomyelitis. Traditional diagnostic methods, including polymerase chain reaction, serological assays, and imaging techniques, though valuable, have limitations. To address these challenges, biosensor‐based methods have emerged as a promising approach. These methods offer advantages such as rapid results, high sensitivity, specificity, and potential for point‐of‐care applications. By targeting specific biomarkers or genetic material, biosensors utilise technologies like surface plasmon resonance and microarrays, providing a direct and efficient means of diagnosing neurotropic infections. This review explores the evolving landscape of biosensor‐based methods, highlighting their potential to enhance the diagnostic toolkit for neurotropic viruses.
ISSN:1052-9276
1099-1654
1099-1654
DOI:10.1002/rmv.2513