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Assessment of toxicity, genotoxicity and oxidative stress in Fejervarya limnocharis exposed to tributyltin
Tributyltin (TBT) is widely used in various commercial applications due to its biocidal properties. Toxicological and genotoxicological data on TBT exposure to amphibians is insufficient. Our study aimed to determine the acute toxicity and genotoxic potential of TBT in Fejervarya limnocharis tadpole...
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| Published in: | Environmental science and pollution research international 2024-02, Vol.31 (10), p.14938-14948 |
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| container_title | Environmental science and pollution research international |
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| creator | Mandal, Abhijit Giri, Sarbani Giri, Anirudha |
| description | Tributyltin (TBT) is widely used in various commercial applications due to its biocidal properties. Toxicological and genotoxicological data on TBT exposure to amphibians is insufficient. Our study aimed to determine the acute toxicity and genotoxic potential of TBT in
Fejervarya limnocharis
tadpoles. Furthermore, oxidative stress was also investigated in TBT-treated tadpoles. Tadpoles of Gosner stage (26–30) were screened and subjected to increasing concentrations of TBT (0, 3, 7, 11, 15, 19, 23 µg/L) for determining the LC
50
values for 24 h, 48 h, 72 h, and 96 h. LC
50
values of TBT for 24 h, 48 h, 72 h, and 96 h were found to be 19.45, 15.07, 13.12, and 11.84 μg/L respectively. Based on the 96 h LC
50
value (11.84 µg/L), tadpoles were exposed to different sub-lethal concentrations of TBT for the evaluation of its genotoxic potential and effects on oxidative balance. The role of TBT on survivability, growth, and time to metamorphosis was also assessed. TBT exposure significantly altered the life history traits measured, increased mortality, and delayed the time taken to metamorphosis. Results indicated significant induction of micronucleus (MN,
p
|
| doi_str_mv | 10.1007/s11356-024-32220-5 |
| format | article |
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Fejervarya limnocharis
tadpoles. Furthermore, oxidative stress was also investigated in TBT-treated tadpoles. Tadpoles of Gosner stage (26–30) were screened and subjected to increasing concentrations of TBT (0, 3, 7, 11, 15, 19, 23 µg/L) for determining the LC
50
values for 24 h, 48 h, 72 h, and 96 h. LC
50
values of TBT for 24 h, 48 h, 72 h, and 96 h were found to be 19.45, 15.07, 13.12, and 11.84 μg/L respectively. Based on the 96 h LC
50
value (11.84 µg/L), tadpoles were exposed to different sub-lethal concentrations of TBT for the evaluation of its genotoxic potential and effects on oxidative balance. The role of TBT on survivability, growth, and time to metamorphosis was also assessed. TBT exposure significantly altered the life history traits measured, increased mortality, and delayed the time taken to metamorphosis. Results indicated significant induction of micronucleus (MN,
p
< 0.001) and other erythrocytic nuclear aberrations (ENA,
p
< 0.01) in the TBT-treated groups. Significant alterations in comet parameters and oxidative balance were also observed in the treated groups. The present study findings might add to the cause of the gradual population decline seen in the amphibians. This study also demonstrates the alteration of the life-history traits, oxidative balance, and DNA damage upon TBT exposure which can have long-term consequences for the anuran amphibian
F. limnocharis
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Fejervarya limnocharis
tadpoles. Furthermore, oxidative stress was also investigated in TBT-treated tadpoles. Tadpoles of Gosner stage (26–30) were screened and subjected to increasing concentrations of TBT (0, 3, 7, 11, 15, 19, 23 µg/L) for determining the LC
50
values for 24 h, 48 h, 72 h, and 96 h. LC
50
values of TBT for 24 h, 48 h, 72 h, and 96 h were found to be 19.45, 15.07, 13.12, and 11.84 μg/L respectively. Based on the 96 h LC
50
value (11.84 µg/L), tadpoles were exposed to different sub-lethal concentrations of TBT for the evaluation of its genotoxic potential and effects on oxidative balance. The role of TBT on survivability, growth, and time to metamorphosis was also assessed. TBT exposure significantly altered the life history traits measured, increased mortality, and delayed the time taken to metamorphosis. Results indicated significant induction of micronucleus (MN,
p
< 0.001) and other erythrocytic nuclear aberrations (ENA,
p
< 0.01) in the TBT-treated groups. Significant alterations in comet parameters and oxidative balance were also observed in the treated groups. The present study findings might add to the cause of the gradual population decline seen in the amphibians. This study also demonstrates the alteration of the life-history traits, oxidative balance, and DNA damage upon TBT exposure which can have long-term consequences for the anuran amphibian
F. limnocharis
.</description><subject>Acute toxicity</subject><subject>Amphibians</subject><subject>Animals</subject><subject>Antifouling substances</subject><subject>Anura</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biocides</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>Fejervarya limnocharis</subject><subject>Genotoxicity</subject><subject>Juveniles</subject><subject>Larva</subject><subject>Life history</subject><subject>Metamorphosis</subject><subject>Metamorphosis, Biological</subject><subject>Oxidative Stress</subject><subject>Population decline</subject><subject>Reptiles & amphibians</subject><subject>Research Article</subject><subject>Survivability</subject><subject>Toxicity</subject><subject>Trialkyltin Compounds - toxicity</subject><subject>Tributyltin</subject><subject>Tributyltin compounds</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><issn>1614-7499</issn><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EoqXlD3BAlrhwINQex7FzrCoKSJV66d3KOpPiVWIvHqfq_ntctgXEoSePNd97M_Zj7J0Un6UQ5oykVLprBLSNAgDR6BfsWHaybUzb9y__qY_YG6KtECB6MK_ZkbJgux7sMdueEyHRgrHwNPGS7oMPZf-J32JMTzc-xJHXehxKuENOJVcJD5Ff4hbz3ZD3A5_DEpP_MeRAHO93iXCsbrzksFnLfi4hnrJX0zATvn08T9jN5Zebi2_N1fXX7xfnV41XRpfGj6YTD_t5O0hrjBoRJhBjBwp1q1s5TQagnbxVnUbcCA3WTGh924kOUZ2wjwfbXU4_V6TilkAe53mImFZy0IOQVivdV_TDf-g2rTnW5SqlhDQgWlspOFA-J6KMk9vlsNRHOyncQxDuEISrQbjfQThdRe8frdfNguMfydPPV0AdAKqteIv57-xnbH8BngGUvQ</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Mandal, Abhijit</creator><creator>Giri, Sarbani</creator><creator>Giri, Anirudha</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0808-729X</orcidid><orcidid>https://orcid.org/0000-0002-2711-103X</orcidid><orcidid>https://orcid.org/0000-0001-7792-8374</orcidid></search><sort><creationdate>20240201</creationdate><title>Assessment of toxicity, genotoxicity and oxidative stress in Fejervarya limnocharis exposed to tributyltin</title><author>Mandal, Abhijit ; Giri, Sarbani ; Giri, Anirudha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cd7608286c8a18773de2f20d623e54541ff7224fc8365eeb05287fe8c4606ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute toxicity</topic><topic>Amphibians</topic><topic>Animals</topic><topic>Antifouling substances</topic><topic>Anura</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Biocides</topic><topic>DNA Damage</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Exposure</topic><topic>Fejervarya limnocharis</topic><topic>Genotoxicity</topic><topic>Juveniles</topic><topic>Larva</topic><topic>Life history</topic><topic>Metamorphosis</topic><topic>Metamorphosis, Biological</topic><topic>Oxidative Stress</topic><topic>Population decline</topic><topic>Reptiles & amphibians</topic><topic>Research Article</topic><topic>Survivability</topic><topic>Toxicity</topic><topic>Trialkyltin Compounds - toxicity</topic><topic>Tributyltin</topic><topic>Tributyltin compounds</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mandal, Abhijit</creatorcontrib><creatorcontrib>Giri, Sarbani</creatorcontrib><creatorcontrib>Giri, Anirudha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mandal, Abhijit</au><au>Giri, Sarbani</au><au>Giri, Anirudha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of toxicity, genotoxicity and oxidative stress in Fejervarya limnocharis exposed to tributyltin</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>31</volume><issue>10</issue><spage>14938</spage><epage>14948</epage><pages>14938-14948</pages><issn>1614-7499</issn><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Tributyltin (TBT) is widely used in various commercial applications due to its biocidal properties. Toxicological and genotoxicological data on TBT exposure to amphibians is insufficient. Our study aimed to determine the acute toxicity and genotoxic potential of TBT in
Fejervarya limnocharis
tadpoles. Furthermore, oxidative stress was also investigated in TBT-treated tadpoles. Tadpoles of Gosner stage (26–30) were screened and subjected to increasing concentrations of TBT (0, 3, 7, 11, 15, 19, 23 µg/L) for determining the LC
50
values for 24 h, 48 h, 72 h, and 96 h. LC
50
values of TBT for 24 h, 48 h, 72 h, and 96 h were found to be 19.45, 15.07, 13.12, and 11.84 μg/L respectively. Based on the 96 h LC
50
value (11.84 µg/L), tadpoles were exposed to different sub-lethal concentrations of TBT for the evaluation of its genotoxic potential and effects on oxidative balance. The role of TBT on survivability, growth, and time to metamorphosis was also assessed. TBT exposure significantly altered the life history traits measured, increased mortality, and delayed the time taken to metamorphosis. Results indicated significant induction of micronucleus (MN,
p
< 0.001) and other erythrocytic nuclear aberrations (ENA,
p
< 0.01) in the TBT-treated groups. Significant alterations in comet parameters and oxidative balance were also observed in the treated groups. The present study findings might add to the cause of the gradual population decline seen in the amphibians. This study also demonstrates the alteration of the life-history traits, oxidative balance, and DNA damage upon TBT exposure which can have long-term consequences for the anuran amphibian
F. limnocharis
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38286928</pmid><doi>10.1007/s11356-024-32220-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0808-729X</orcidid><orcidid>https://orcid.org/0000-0002-2711-103X</orcidid><orcidid>https://orcid.org/0000-0001-7792-8374</orcidid></addata></record> |
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| subjects | Acute toxicity Amphibians Animals Antifouling substances Anura Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Biocides DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Exposure Fejervarya limnocharis Genotoxicity Juveniles Larva Life history Metamorphosis Metamorphosis, Biological Oxidative Stress Population decline Reptiles & amphibians Research Article Survivability Toxicity Trialkyltin Compounds - toxicity Tributyltin Tributyltin compounds Waste Water Technology Water Management Water Pollutants, Chemical - toxicity Water Pollution Control |
| title | Assessment of toxicity, genotoxicity and oxidative stress in Fejervarya limnocharis exposed to tributyltin |
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