High Contrast Bioimaging of Tumor and Inflammation with a Bicyclic Dioxetane Chemiluminescent Probe

The link between inflammation and the evolution of cancer is well established. Visualizing and tracking both tumor proliferation and the associated inflammatory response within a living organism are vital for dissecting the nexus between these two processes and for crafting precise treatment modalit...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2024-02, Vol.96 (6), p.2286-2291
Main Authors: Shang, Qian, Li, Shen-Huan, He, Yu-Ting, Zhang, Yun, Fu, Ting, Han, Shi-Song, Huang, Wenshan, Wang, Xue-Qiang, Xu, Jie-Hua
Format: Article
Language:English
Subjects:
Cancer
Chemiluminescence
Inflammation
Inflammatory response
Medical imaging
Steering
Tumors
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Summary:The link between inflammation and the evolution of cancer is well established. Visualizing and tracking both tumor proliferation and the associated inflammatory response within a living organism are vital for dissecting the nexus between these two processes and for crafting precise treatment modalities. We report the creation and synthesis of an advanced NIR chemiluminescence probe that stands out for its exceptional selectivity, extraordinary sensitivity at nanomolar concentrations, swift detection capabilities, and broad application prospects. Crucially, this probe has been successfully utilized to image endogenous ONOO– across different inflammation models, including abdominal inflammation triggered by LPS, subcutaneous inflammatory conditions, and tumors grafted onto mice. These findings highlight the significant promise of chemiluminescence imaging in enhancing our grasp of the intricate interplay between cancer and inflammation and in steering the development of potent, targeted therapeutic strategies.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.3c05062