MicroRNA‐196a‐5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy affecting the digestive tract, with an increasing incidence rate worldwide. Recently, numerous studies revealed that microRNAs were associated with gene expression regulation, particularly their involvement in the regulation of tumo...

Full description

Saved in:
Bibliographic Details
Published in:Pathology international 2024-03, Vol.74 (3), p.129-138
Main Authors: Xian, Dubiao, Yang, Shubo, Liu, Yunzhong, Liu, Qingfeng, Huang, Ding, Wu, Yuechang
Format: Article
Language:English
Subjects:
Animal models
Apoptosis
Bioinformatics
Esophageal cancer
Esophageal carcinoma
esophageal squamous cell carcinoma
Gastrointestinal tract
Gene expression
ITM2B
Malignancy
MicroRNAs
miRNA
miR‐196a‐5p
Phenotypes
Regulatory mechanisms (biology)
Squamous cell carcinoma
Tumor cells
tumorigenesis
Xenotransplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy affecting the digestive tract, with an increasing incidence rate worldwide. Recently, numerous studies revealed that microRNAs were associated with gene expression regulation, particularly their involvement in the regulation of tumor cells, garnering widespread attention. Here, we discovered that miR‐196a‐5p was significantly upregulated in both ESCC tissues and cells, which was correlated with an unfavorable prognosis. Series functional in vitro investigations have confirmed that silencing miR‐196a‐5p obviously restrained the ESCC cells malignant phenotypes and promoted apoptosis. Bioinformatics analysis and rescue experiments revealed that miR‐196a‐5p directly targeted ITM2B, exerting influence on the development of ESCC cells through negative regulation of ITM2B expression. Xenograft mouse models were established for conducting in vivo experiments, providing further confirmation of the regulatory mechanism and biological significance of the miR‐196a‐5p/ITM2B axis in ESCC. Our research demonstrated miR‐196a‐5p promoted ESCC malignant progression by interacting with ITM2B, thereby providing novel clues and potential targets for the new diagnosis and thereby of ESCC.
ISSN:1320-5463
1440-1827
DOI:10.1111/pin.13408