Sentinel lymph node biopsy in endometrial cancer: When, how and in which patients

The role of nodal dissection in patients with endometrial cancer has been intensively studied in several studies. Historically, systematic pelvic and para-aortic lymphadenectomy represented the gold standard surgical treatment to assess potential nodal involvement and consequently define the appropr...

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Bibliographic Details
Published in:European journal of surgical oncology 2024-03, Vol.50 (3), p.107956-107956, Article 107956
Main Authors: Leone Roberti Maggiore, Umberto, Spanò Bascio, Ludovica, Alboni, Carlo, Chiarello, Giulia, Savelli, Luca, Bogani, Giorgio, Martinelli, Fabio, Chiappa, Valentina, Ditto, Antonino, Raspagliesi, Francesco
Format: Article
Language:English
Subjects:
Endometrial cancer
Endometrial Neoplasms - pathology
Endometrial Neoplasms - surgery
Female
Humans
Lymph Node Excision - methods
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphadenectomy
Lymphatic Metastasis - pathology
Neoplasm Staging
Outcome
Sentinel Lymph Node - pathology
Sentinel Lymph Node Biopsy - methods
Sentinel node
Surgery
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Summary:The role of nodal dissection in patients with endometrial cancer has been intensively studied in several studies. Historically, systematic pelvic and para-aortic lymphadenectomy represented the gold standard surgical treatment to assess potential nodal involvement and consequently define the appropriate stage of the tumor. Over the last years, sentinel node biopsy (SLNB) has been introduced as a more targeted alternative to lymph node dissection for lymph node staging and it has become popular among gynecologic oncologists. However, no level A evidence is still available, and several features of the SLNB technique have been matter of discussion among clinicians and a universally accepted methodology is still not currently available. This narrative review aims to summarize the body of knowledge on SLNB to offer the reader a complete picture about the evolution of this technique over the last decades.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2024.107956