Detailed aggregate exposure analysis shows that exposure to fragrance ingredients in consumer products is low: Many orders of magnitude below thresholds of concern

• Published in: Regulatory toxicology and pharmacology 2024-03, Vol.148, p.105569-105569, Article 105569
• Main Authors: Lee, Isabelle, Scrochi, Cesar, Chon, Olive, Cancellieri, Mary Ann, Ghosh, Ambarnil, O'Brien, John, Ring, Brendan, McNamara, Cronan, Api, Anne Marie
• Format: Article
• Language: English
• Subjects: Aggregate exposure; Creme RIFM aggregate exposure model; DST; Exposure; Fragrance ingredient; Fragrance safety; Safety assessment; TTC
• ISSN: 0273-2300; 1096-0295
• DOI: 10.1016/j.yrtph.2024.105569

The Research Institute for Fragrance Materials (RIFM) and Creme Global Cremeglobal.com partnered to develop an aggregate exposure model for fragrance ingredients. The model provides a realistic estimate of the total exposure of fragrance ingredients to individuals across a population. The Threshold of Toxicological Concern (TTC) and Dermal Sensitization Threshold (DST) were used to demonstrate the magnitude of low exposure to fragrance materials. The total chronic systemic, inhalation, and dermal 95th percentile exposures on approximately 3000 fragrance ingredients in RIFM's inventory were compared to their respective TTC or DST. Additionally, representative fragrance ingredients were randomly selected and analyzed for exposure distribution by product type (i.e., cosmetic/personal care, household care, oral care, and air care) and route of exposure. It was found that 76 % of fragrance ingredients fall below their respective TTC limits when compared to 95th percentile systemic exposure, while 99 % are below inhalation TTC limits. The lowest 95th percentile aggregate exposure by product type was from household care products, then air care, and oral care products. The highest exposure was from personal care/cosmetic products. The volume of use for most fragrance ingredients (63 %) was