Lipids as mediators of cancer progression and metastasis

Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism...

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Bibliographic Details
Published in:Nature cancer 2024-01, Vol.5 (1), p.16-29
Main Authors: Vogel, Felix C E, Chaves-Filho, Adriano B, Schulze, Almut
Format: Article
Language:English
Subjects:
Humans
Lipids
Neoplasms
Oxidative Stress
Signal Transduction
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Summary:Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers.
ISSN:2662-1347
2662-1347
DOI:10.1038/s43018-023-00702-z