Injectable hydrogels as promising in situ therapeutic platform for cartilage tissue engineering

Injectable hydrogels are gaining prominence as a biocompatible, minimally invasive, and adaptable platform for cartilage tissue engineering. Commencing with their synthesis, this review accentuates the tailored matrix formulations and cross-linking techniques essential for fostering three-dimensiona...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-03, Vol.261 (Pt 1), p.129537-129537, Article 129537
Main Authors: Cai, Rong, Shan, Yisi, Du, Fengyi, Miao, Zhiwei, Zhu, Like, Hang, Li, Xiao, Long, Wang, Zhirong
Format: Article
Language:English
Subjects:
Cartilage
Cartilage tissue engineering
Chondrocyte
Cross-Linking Reagents - chemistry
Hydrogels - chemistry
Hydrogels - pharmacology
Injectable hydrogel
Regenerative Medicine
Tissue Engineering - methods
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Summary:Injectable hydrogels are gaining prominence as a biocompatible, minimally invasive, and adaptable platform for cartilage tissue engineering. Commencing with their synthesis, this review accentuates the tailored matrix formulations and cross-linking techniques essential for fostering three-dimensional cell culture and melding with complex tissue structures. Subsequently, it spotlights the hydrogels' enhanced properties, highlighting their augmented functionalities and broadened scope in cartilage tissue repair applications. Furthermore, future perspectives are advocated, urging continuous innovation and exploration to surmount existing challenges and harness the full clinical potential of hydrogels in regenerative medicine. Such advancements are crucial for validating the long-term efficacy and safety of hydrogels, positioning them as a promising direction in regenerative medicine to address cartilage-related ailments.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2024.129537