Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis

•The consequences of chronic hepatitis c may depend on the effect of several factors.•53 % of patients with chronic hepatitis c had hepatic steatosis.•The −164T/C and −493 G/T polymorphisms in the MTTP gene showed a combined effect on steatosis.•This combined effect may increase the chance of presen...

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Published in:Clinics and research in hepatology and gastroenterology 2024-03, Vol.48 (3), p.102291, Article 102291
Main Authors: Prata, Thamiris Vaz Gago, Paula, Victória Gonçalves de, Passos, Lhays Ozório, Brogiato, Vitória Luiza Batalhoti, Ferreira, Gustavo Manoel, Manchiero, Caroline, Dantas, Bianca Peixoto, Battaglia, Débora Bignotto Rosane, Figueiredo, Gerusa Maria, Tengan, Fátima Mitiko, Magri, Mariana Cavalheiro
Format: Article
Language:English
Subjects:
Fatty Liver - genetics
Genotype
Hepacivirus - genetics
Hepatic steatosis
Hepatitis C virus (HCV)
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - genetics
Humans
Interaction
Microsomal triglyceride transfer protein (MTTP)
Polymorphism, Genetic
Polymorphisms
Thymine Nucleotides
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Summary:•The consequences of chronic hepatitis c may depend on the effect of several factors.•53 % of patients with chronic hepatitis c had hepatic steatosis.•The −164T/C and −493 G/T polymorphisms in the MTTP gene showed a combined effect on steatosis.•This combined effect may increase the chance of presenting steatosis by 12.83 times.
ISSN:2210-7401
2210-741X
2210-741X
DOI:10.1016/j.clinre.2024.102291