Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis

•The consequences of chronic hepatitis c may depend on the effect of several factors.•53 % of patients with chronic hepatitis c had hepatic steatosis.•The −164T/C and −493 G/T polymorphisms in the MTTP gene showed a combined effect on steatosis.•This combined effect may increase the chance of presen...

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Published in:Clinics and research in hepatology and gastroenterology 2024-03, Vol.48 (3), p.102291, Article 102291
Main Authors: Prata, Thamiris Vaz Gago, Paula, Victória Gonçalves de, Passos, Lhays Ozório, Brogiato, Vitória Luiza Batalhoti, Ferreira, Gustavo Manoel, Manchiero, Caroline, Dantas, Bianca Peixoto, Battaglia, Débora Bignotto Rosane, Figueiredo, Gerusa Maria, Tengan, Fátima Mitiko, Magri, Mariana Cavalheiro
Format: Article
Language:English
Subjects:
Fatty Liver - genetics
Genotype
Hepacivirus - genetics
Hepatic steatosis
Hepatitis C virus (HCV)
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - genetics
Humans
Interaction
Microsomal triglyceride transfer protein (MTTP)
Polymorphism, Genetic
Polymorphisms
Thymine Nucleotides
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container_issue 3
container_start_page 102291
container_title Clinics and research in hepatology and gastroenterology
container_volume 48
creator Prata, Thamiris Vaz Gago
Paula, Victória Gonçalves de
Passos, Lhays Ozório
Brogiato, Vitória Luiza Batalhoti
Ferreira, Gustavo Manoel
Manchiero, Caroline
Dantas, Bianca Peixoto
Battaglia, Débora Bignotto Rosane
Figueiredo, Gerusa Maria
Tengan, Fátima Mitiko
Magri, Mariana Cavalheiro
description •The consequences of chronic hepatitis c may depend on the effect of several factors.•53 % of patients with chronic hepatitis c had hepatic steatosis.•The −164T/C and −493 G/T polymorphisms in the MTTP gene showed a combined effect on steatosis.•This combined effect may increase the chance of presenting steatosis by 12.83 times.
doi_str_mv 10.1016/j.clinre.2024.102291
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subjects Fatty Liver - genetics
Genotype
Hepacivirus - genetics
Hepatic steatosis
Hepatitis C virus (HCV)
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - genetics
Humans
Interaction
Microsomal triglyceride transfer protein (MTTP)
Polymorphism, Genetic
Polymorphisms
Thymine Nucleotides
title Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis
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