Antimicrobial activity of hydralazine against methicillin-resistant and methicillin-susceptible Staphylococcus aureus

• Published in: Future microbiology 2024-01, Vol.19 (2), p.91-106
• Main Authors: Stefany Aires do Nascimento, Francisca B, do Amaral Valente Sá, Lívia Gurgel, de Andrade Neto, João B, da Silva, Lisandra Juvêncio, Rodrigues, Daniel Sampaio, de Farias Cabral, Vitória P, Barbosa, Amanda Dias, Almeida Moreira, Lara E, Braga Vasconcelos, Camille R, Cavalcanti, Bruno Coêlho, França Rios, Maria E, Silva, Jacilene, Marinho, Emmanuel Silva, Dos Santos, Helcio Silva, de Mesquita, Jacó Rl, Pinto Lobo, Marina Duarte, de Moraes, Manoel Odorico, Nobre Júnior, Hélio V, da Silva, Cecília Rocha
• Format: Article
• Language: English
• ISSN: 1746-0913; 1746-0921
• DOI: 10.2217/fmb-2023-0160

is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin (50%) and vancomycin (25%). Hydralazine reduced the viability of biofilms by 50%. After exposure to hydralazine 2× MIC, 58.78% of the cells were unviable, 62.07% were TUNEL positive and 27.03% presented damage in the comet assay (p