Advanced technologies towards improved HPV diagnostics

Persistent infection with high‐risk types of human papillomaviruses (HPV) is a major cause of cervical cancer, and an important factor in other malignancies, for example, head and neck cancer. Despite recent progress in screening and vaccination, the incidence and mortality are still relatively high...

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Bibliographic Details
Published in:Journal of medical virology 2024-02, Vol.96 (2), p.e29409-n/a
Main Authors: Bartosik, Martin, Moranova, Ludmila, Izadi, Nasim, Strmiskova, Johana, Sebuyoya, Ravery, Holcakova, Jitka, Hrstka, Roman
Format: Article
Language:English
Subjects:
Cancer
Cervical cancer
CRISPR
CRISPR‐Cas
Female
Head & neck cancer
Human papillomavirus
Human Papillomavirus Viruses
Humans
Instrumentation
isothermal amplification techniques
Lab-on-a-chip
lateral flow assay
Malignancy
Microfluidics
Mortality
nanomaterials
Papillomaviridae - genetics
Papillomavirus Infections - complications
Technology
Uterine Cervical Neoplasms
Vaccination
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Summary:Persistent infection with high‐risk types of human papillomaviruses (HPV) is a major cause of cervical cancer, and an important factor in other malignancies, for example, head and neck cancer. Despite recent progress in screening and vaccination, the incidence and mortality are still relatively high, especially in low‐income countries. The mortality and financial burden associated with the treatment could be decreased if a simple, rapid, and inexpensive technology for HPV testing becomes available, targeting individuals for further monitoring with increased risk of developing cancer. Commercial HPV tests available in the market are often relatively expensive, time‐consuming, and require sophisticated instrumentation, which limits their more widespread utilization. To address these challenges, novel technologies are being implemented also for HPV diagnostics that include for example, isothermal amplification techniques, lateral flow assays, CRISPR‐Cas‐based systems, as well as microfluidics, paperfluidics and lab‐on‐a‐chip devices, ideal for point‐of‐care testing in decentralized settings. In this review, we first evaluate current commercial HPV tests, followed by a description of advanced technologies, explanation of their principles, critical evaluation of their strengths and weaknesses, and suggestions for their possible implementation into medical diagnostics.
ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.29409