Identifying left ventricular dysfunction using prospective electrocardiogram-triggered coronary computed tomography angiography

Coronary computed tomography angiography (CCTA) is an important non-invasive tool for the assessment of coronary artery disease and the delivery of information incremental to coronary anatomy. CCTA measured left ventricular (LV) mid-diastolic volume (LVMDV) and LV mass (LVMass) have important progno...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular computed tomography 2024-03, Vol.18 (2), p.187-194
Main Authors: Sharma, Ashwin, Erthal, Fernanda, Juneau, Daniel, Alzahrani, Atif, Alenazy, Ali, Massalha, Samia, Yam, Yeung, Kabir, Bilaal, Small, Gary R., Chow, Benjamin J.W.
Format: Article
Language:English
Subjects:
Computed Tomography Angiography - methods
Coronary Angiography - methods
Coronary computed tomography angiography
Electrocardiography
Female
Heart failure
Humans
Left ventricular ejection fraction
Left ventricular mass
Male
Mid-diastolic volume
Predictive Value of Tests
Prospective Studies
Stroke Volume
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Function, Left
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coronary computed tomography angiography (CCTA) is an important non-invasive tool for the assessment of coronary artery disease and the delivery of information incremental to coronary anatomy. CCTA measured left ventricular (LV) mid-diastolic volume (LVMDV) and LV mass (LVMass) have important prognostic information but the utility of prospectively ECG-triggered CCTA to predict reduced left ventricular ejection fraction (LVEF) is unknown. The objective of this study was to determine if indexed LVMDV (LVMDVi) and the LVMDV:LVMass ratio on CCTA can identify patients with reduced LVEF. 8179 patients with prospectively ECG-triggered CCTA between November 2014 and December 2019 were reviewed. A subset derivation cohort of 4352 healthy patients was used to define normal LVMDVi and LVMDV:LVMass. Sex-specific thresholds were tested in a validation cohort of 1783 patients, excluded from the derivation cohort, with cardiac disease and known LVEF. The operating characteristics for 1 SD above the mean were tested for the identification of abnormal LVEF, LVEF≤35 ​% and ≤30 ​%. The derivation cohort had a mean LVMDVi of 61.0 ​± ​13.7 ​mL/m2 and LVMDV:LVMass of 1.11 ​± ​0.24 ​mL/g. LVMDVi and LVMDV:LVMass were both higher in patients with reduced LVEF than those with normal LVEF (98.8 ​± ​40.8 ​mL/m2 vs. 63.3 ​± ​19.7 ​mL/m2, p ​
ISSN:1934-5925
1876-861X
DOI:10.1016/j.jcct.2024.01.009