Predictors of Psoriasis Area and Severity Index 100 response in Korean patients with moderate-to-severe plaque psoriasis receiving biologics

Background The Psoriasis Area and Severity Index (PASI) 100 response rate after treatment with biologics is reportedly lower in Asians than non-Asians. Large-scale studies evaluating predictors of PASI 100 response in Korean patients with psoriasis are yet to be conducted. Objectives To identify pre...

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Bibliographic Details
Published in:EJD. European journal of dermatology 2023-10, Vol.33 (5), p.518-523
Main Authors: Kim, Tae-Rim, Won, Yumi, Kim, Yeona, Won, Sang-Hyeon, Bae, Kyung-Nam, Lee, Jungsoo, Shin, Kihyuk, Kim, Hoonsoo, Ko, Hyunchang, Kim, Moon-Bum, Kim, Byungsoo
Format: Article
Language:English
Subjects:
Biological Factors - therapeutic use
Biological Products - therapeutic use
Clinical Report
Dermatology
Humans
Medicine
Medicine & Public Health
Psoriasis - drug therapy
Republic of Korea
Retrospective Studies
Severity of Illness Index
Treatment Outcome
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Summary:Background The Psoriasis Area and Severity Index (PASI) 100 response rate after treatment with biologics is reportedly lower in Asians than non-Asians. Large-scale studies evaluating predictors of PASI 100 response in Korean patients with psoriasis are yet to be conducted. Objectives To identify predictors of patients achieving PASI 100 response after 48–52 weeks of treatment with a biological agent. Materials & Methods We retrospectively reviewed the medical records of 145 patients with psoriasis treated with a single biological agent for over one year. Clinical features were compared between super-responders (defined as achieving PASI 100 at 48–52 weeks) and non-super-responders. Results Among the patients included in the study, 61 (42.1%) were super-responders. No statistical difference in demographics and face, scalp, or nail involvement was observed. However, the mean body mass index (BMI) and baseline PASI were lower in super-responders (24.3 kg/m 2 , 14.3) than in non-super-responders (26.1 kg/m 2 , 16.2). There were more biologically naïve patients among the super-responders (85.2%) than the non-super-responders (67.9%). Conclusion In Korean patients with moderate-to-severe psoriasis, a better PASI 100 response is expected for patients who are biologically naïve with a relatively lower baseline BMI and PASI.
ISSN:1167-1122
1952-4013
DOI:10.1684/ejd.2023.4555