The role of serum asprosin levels in predicting the severity of coronary artery disease in patients with diabetes mellitus

Background Asprosin is an emerging biomarker that plays a role in metabolic diseases. This study investigates asprosin as a predictive marker for coronary artery disease (CAD) severity in diabetic patients. Methods Diabetic patients ( n  = 181) and healthy controls ( n  = 60) were analyzed. CAD seve...

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Published in:Irish journal of medical science 2024-06, Vol.193 (3), p.1239-1247
Main Authors: Yigitdol, Ismail, Gulumsek, Erdinc, Demirtas, Derya, Ardic, Mustafa Lutfullah, Baylan, Filiz Alkan, Ozturk, Huseyin Ali, Arici, Fatih Necip, Seker, Taner, Sumbul, Hilmi Erdem
Format: Article
Language:English
Subjects:
Adipokines
Aged
Biomarkers - blood
Case-Control Studies
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Diabetes Mellitus - blood
Extracellular Matrix Proteins - blood
Family Medicine
Female
Fibrillin-1 - blood
General Practice
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Severity of Illness Index
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Summary:Background Asprosin is an emerging biomarker that plays a role in metabolic diseases. This study investigates asprosin as a predictive marker for coronary artery disease (CAD) severity in diabetic patients. Methods Diabetic patients ( n  = 181) and healthy controls ( n  = 60) were analyzed. CAD severity was assessed using SYNTAX score. Diabetic patients were divided into 3 groups. Group 1 = patients without CAD, group 2 = patients with low SYNTAX score, and group 3 = patients with moderate-high SYNTAX score. Asprosin levels were measured for all participants using an enzyme-linked immunosorbent assay (ELISA). Results Asprosin levels were significantly higher in patient group compared to control group ( p  
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-024-03616-6