Altered small-world and disrupted topological properties of functional connectivity networks in patients with nonarteritic anterior ischemic optic neuropathy

• Published in: Clinical neurology and neurosurgery 2024-01, Vol.236, p.108101-108101, Article 108101
• Main Authors: Wang, Hui, Yan, Xiaoling, Zhang, Qiuhuan, Wu, Qiong, Qiu, Lixin, Zhou, Jian, Guo, Pengde
• Format: Article
• Language: English
• Subjects: Brain - diagnostic imaging; Brain Mapping - methods; Brain research; Cerebellum; Disease; Edema; Efficiency; Functional connectivity; Functional magnetic resonance imaging; Glaucoma; Graph theory; Humans; Ischemia; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Neural networks; Nonarteritic anterior ischemic optic neuropathy; Optic nerve; Optic neuropathy; Optic Neuropathy, Ischemic - diagnostic imaging; Resting-state functional magnetic resonance imaging; Statistical analysis; Superior temporal gyrus; Temporal gyrus; Temporal Lobe; Visual acuity
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2023.108101

Nonarteritic anterior ischemic optic neuropathy (NAION) is a disease of the optic nerve, but its effect on brain network topology is still unclear.This study aimed to investigate brain network alterations in NAION patients and to explore their relationship with functional impairment. Resting-state functional MRI data were collected from 23 NAION patients and 23 matched healthy control subjects.We used graph theory analysis to investigate the global and nodal network topological properties,and network-based statistical (NBS) methods were used to explore intergroup differences in functional connectivity (FC) strength. Compared to the control group, NAION patients had lower global efficiency, normalized clustering coefficient and small-world values and higher characteristic path length (P