Non-structural protein 1 and hematology parameters as predictors of dengue virus infection severity in Indonesia

Dengue virus infection (DVI) remains a significant health challenge, and diagnosis must still be considered. Non-structural protein 1 (NS1) is a potential marker of the dengue virus that can help diagnose DVI. The study aimed to assess the role of NS1 as a predictor of the severity of DVI. We utiliz...

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Bibliographic Details
Published in:Journal of medicine and life 2023-10, Vol.16 (10), p.1546-1551
Main Authors: Sunari, I Gusti Agung Ayu Eka Putri, Aryati, Aryati, Hakim, Faradila Khoirun Nisa, Tanzilia, May Fanny, Zuroidah, Nelly, Wrahatnala, Billy Jordan, Rohman, Ali, Wardhani, Puspa, Husada, Dominicus, Miftahussurur, Muhammad
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral
Antigens
Chikungunya virus
Child
Dengue - diagnosis
Dengue fever
Dengue Virus - metabolism
Enzyme-Linked Immunosorbent Assay
Enzymes
Hematology
Humans
Immunoassay
Indonesia - epidemiology
Infections
Infectious diseases
Leukocytes
Lipids
Pathogenesis
Polymerase chain reaction
Proteins
Research methodology
Sensitivity and Specificity
Tropical diseases
Viral infections
Viral Nonstructural Proteins - analysis
Viral Nonstructural Proteins - metabolism
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Summary:Dengue virus infection (DVI) remains a significant health challenge, and diagnosis must still be considered. Non-structural protein 1 (NS1) is a potential marker of the dengue virus that can help diagnose DVI. The study aimed to assess the role of NS1 as a predictor of the severity of DVI. We utilized Dengue PCR-confirmed samples and employed semi-quantitative NS1Ag ELISA for NS1 examination, adhering to the World Health Organization South-East Asia Region (WHO-SEARO) 2011 criteria for DVI. We included DVI patients from Indonesia aged 1-65 years. Secondary infections had more severe clinical conditions than primary infections. Leukocyte and platelet levels had a more significant effect on NS1 positivity (6.19 (1.9-30.2); p
ISSN:1844-3117
1844-122X
1844-3117
DOI:10.25122/jml-2022-0300