Impact of deep muscle invasion on nodal status and survival in patients with pT2 esophageal squamous cancer

Background Whether T2 esophageal squamous cell carcinoma should be subclassified remains controversial. We aimed to investigate the impact of the depth of muscularis propria invasion on nodal status and survival outcomes. Methods We identified patients with pT2 esophageal squamous cell carcinoma who...

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Bibliographic Details
Published in:Journal of surgical oncology 2024-05, Vol.129 (6), p.1056-1062
Main Authors: Yan, Cheng‐Yi, Gu, Yi‐Min, Shi, Gui‐Dong, Shang, Qi‐Xin, Zhang, Han‐Lu, Yang, Yu‐Shang, Wang, Wen‐Ping, Yuan, Yong, Chen, Long‐Qi
Format: Article
Language:English
Subjects:
Aged
depth of muscularis propria invasion
Esophageal cancer
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
esophageal squamous cell carcinoma
Esophageal Squamous Cell Carcinoma - mortality
Esophageal Squamous Cell Carcinoma - pathology
Esophageal Squamous Cell Carcinoma - surgery
Esophagectomy
Female
Follow-Up Studies
Humans
lymph node metastasis
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
Lymphatic system
Male
Metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Prospective Studies
Regression analysis
Retrospective Studies
Squamous cell carcinoma
subclassification
survival
Survival Rate
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Summary:Background Whether T2 esophageal squamous cell carcinoma should be subclassified remains controversial. We aimed to investigate the impact of the depth of muscularis propria invasion on nodal status and survival outcomes. Methods We identified patients with pT2 esophageal squamous cell carcinoma who underwent primary surgery from January 2009 to June 2017. Clinical data were extracted from prospectively maintained databases. Tumor muscularis propria invasion was stratified into superficial or deep. Binary logistic regression was used to determine risk factors for lymph node metastases. The impact of the depth of muscularis propria invasion on survival was investigated using Kaplan‒Meier analysis and a Cox proportional hazard regression model. Results A total of 750 patients from three institutes were investigated. The depth of muscularis propria invasion (odds ratio [OR]: 3.95, 95% confidence interval [CI]: 2.46–6.35; p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.27593