Frailty-Related Factors among Women Living with and without HIV Aged 40 Years and Older. The Women's Interagency HIV Study

Frailty is a clinical, geriatric syndrome linked to disability and mortality; and may be associated with a variety of factors among underrepresented and underserved women living with HIV (WLWH) and without HIV (WLWOH) transitioning through the adult life course. Determine whether a published set of...

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Bibliographic Details
Published in:The Journal of frailty & aging 2024-01, Vol.13 (1), p.40-49
Main Authors: Gustafson, D R, Shi, Q, Thurn, M, Holman, S, Kuniholm, M H, Fischl, M, Floris-Moore, M, Gange, S, Konkle-Parker, D, Plankey, M, Price, J C, Ross, R D, Rubtsova, A, Sharma, A, Hoover, D R
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Age
AIDS
Body mass index
Cancer
Chronic illnesses
Cohort analysis
Frailty
Health behavior
HIV
Human immunodeficiency virus
Immune response
Infectious diseases
Life course
Obesity
Older women
Quality of life
Smoking
Sociodemographics
Tuberculosis
Underserved populations
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Summary:Frailty is a clinical, geriatric syndrome linked to disability and mortality; and may be associated with a variety of factors among underrepresented and underserved women living with HIV (WLWH) and without HIV (WLWOH) transitioning through the adult life course. Determine whether a published set of factors associated cross-sectionally with frailty in WLWH and similar WLWOH at average age 39 years in 2005/2006 were associated with frailty in 2018/2019 among women who initiated frailty assessments at age ≥40 years, or whether a new set of factors were associated with frailty. Cross-sectional analyses within a longitudinal cohort study. The multi-center Women's Interagency HIV Study (WIHS). 1285 participants (951 WLWH, 334 WLWOH), median age 53 years (interquartile range 47-58 years). The Fried Frailty Phenotype (FFP) in association with 23 factors representing HIV serostatus, other infections, sociodemographic factors, health behaviors, and chronic diseases. Frailty prevalence was 11.1% in 2018/2019 (12.6% among WLWOH, 9.6% among WLWH, p=0.121). The published 2005/2006 final multivariable stepwise regression model contained 9 predictors of frailty. When refit to women in 2018/2019, only age ≥50 years and annual income ≤$12,000 were independently positively associated with frailty; other significant 2005/2006 factors, HIV serostatus, CD4+ count
ISSN:2260-1341
2273-4309
DOI:10.14283/jfa.2023.41